Marco RubioMarco Antonio RubioHome state candidates risk losing primaries The Hill's Morning Report - Presented by Facebook - Trump on US coronavirus risks: 'We're very, very ready for this' Overnight Energy: Critics pile on Trump plan to roll back major environmental law | Pick for Interior No. 2 official confirmed | JPMorgan Chase to stop loans for fossil fuel drilling in the Arctic MORE ridiculed Donald TrumpDonald John TrumpTrump endorses former White House physician Ronny Jackson for Congress Newly released emails reveal officials' panic over loss of credibility after Trump's Dorian claims Lindsey Graham thanks Trump, bemoans 'never-ending bull----' at South Carolina rally  MORE's approach to finding Middle East peace, saying that Israeli-Palestinian talks are not like a real estate deal.

"The Palestinians are not a real estate deal, Donald," the White House contender said in Thursday night's CNN Republican debate in Houston.

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Rubio and Ted CruzRafael (Ted) Edward CruzGOP chairwoman suggests RNC plans to get 'litigious' over push for national popular vote The Hill's Campaign Report: Sanders top target at CPAC Bloomberg campaign manager says they have considered naming running mate during primaries MORE both hit the billionaire businessman for saying that he would be a neutral broker in peace negotiations between the Israelis and the Palestinians.

Both Rubio and Cruz say they would stand unequivocally with Israel, while the party front-runner argues that neutrality is required to make what would be "probably the toughest deal of any kind."

"A deal is a deal," Trump replied, when Rubio made the point that Middle East peace talks had nothing to do with negotiating real estate.

Rubio hit back: "A deal is not a deal when you're dealing with terrorists. Have you ever negotiated with terrorists?"

Trump, who was under attack from the Florida senator all night, replied, "You are not a negotiator. And with your thinking you will never bring peace."

"Donald might be able to build condos in the Palestinian areas, but ... this is not a real estate deal," Rubio said to close the exchange.