Marco RubioMarco Antonio RubioPast criticism of Trump becomes potent weapon in GOP primaries Lawmakers urge Biden to be tough on cybersecurity during summit with Putin Five years after the Pulse nightclub massacre the fight for LGBTQ+ rights continues MORE took aim at Donald TrumpDonald TrumpKushner lands book deal, slated for release in 2022 Biden moves to undo Trump trade legacy with EU deal Progressives rave over Harrison's start at DNC MORE’s manhood during a rally Friday morning, portraying the GOP front-runner as a coward and suggesting he may have wet himself during Thursday night's presidential debate.

"He called me Mr. Meltdown. Let me tell you something, last night during two of the debates, he went backstage, he was having a meltdown," Rubio said in Dallas. 

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"First, he had this little makeup thing applying makeup around his mustache because he had one of those sweat mustaches. Then, he he asked for a full length mirror … maybe to make sure his pants weren’t wet."

The line came as Rubio took out his cellphone and began to read Trump's tweets from stage. Noting that some had misspellings, he cracked that the billionaire businessman "must have hired a foreign worker to do his own tweets."

He chided Trump for trying to portray himself as a "tough guy" and said voters shouldn’t be fooled.

"This is a con-job where he is going to Americans who are struggling, Americans who are hurting, and he’s implying, 'I'm fighting for you' because he’s a tough guy. A tough guy? This guy inherited $200 million, he’s never faced any struggle," Rubio said. 

“The other day, he told somebody, a protestor, 'I'm going to punch you in the face.' Donald Trump has never punched anyone else in the face. Donald Trump was the first guy to beg for Secret Service protection.” 

The attacks come the morning after a surprisingly contentious debate, hosted in Houston by CNN, that largely pitted the Florida senator against Trump in a series of attacks. The GOP race pivots to Super Tuesday in just days, when one-quarter of the race's total GOP delegates are up for grabs.