Sen. Marco RubioMarco Antonio RubioGOP chairman vows to protect whistleblowers following Vindman retirement over 'bullying' Lincoln Project offers list of GOP senators who 'protect' Trump in new ad GOP Miami mayor does not commit to voting for Trump MORE (Fla.) is attacking rival Donald TrumpDonald John TrumpDavis: Supreme Court decision is bad news for Trump, good news for Vance Meadows trying to root out suspected White House leakers by feeding them info: Axios Pressley hits DeVos over reopening schools: 'I wouldn't trust you to care for a house plant let alone my child' MORE over one of his biggest weaknesses: his short fingers. 

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Rubio pointed out Trump’s “small hands” in comparison to the billionaire’s height at a campaign rally Sunday night. 

“You know what they say about men with small hands … you can’t trust 'em!” Rubio said.

Comments on Trump’s fingers have been known to set him off. 

In a November 2015 column for Vanity Fair, editor Graydon Carter detailed how the Republican front-runner responds to criticism about his fingers. 

“Just to drive him a little bit crazy, I took to referring to him as a ‘short-fingered vulgarian’ in the pages of Spy magazine,” Carter wrote. “That was more than a quarter of a century ago.” 

In 1988, Spy magazine referred to Trump as the "short-fingered vulgarian" in nearly every story. 

Trump defended himself in the New York Post, saying, “My fingers are long and beautiful, as, has been well-documented, are various other parts of my body.” 

Carter wrote that he still receives occasional photos from Trump in response to the criticism decades ago.

“On all of [the photos] he has circled his hand in gold Sharpie in a valiant effort to highlight the length of his fingers,” Carter said. “I almost feel sorry for the poor fellow because, to me, the fingers still look abnormally stubby.” 

The most recent photo arrived in 2015, before Trump announced he was running for president. 

“Like the other packages, this one included a circled hand and the words, also written in gold Sharpie: ‘See not so short!’ I sent the picture back … with a note attached saying, ‘Actually, quite short.’ 

“Which I can only assume gave him fits,” Carter wrote.