Ted CruzRafael (Ted) Edward CruzSupreme Court appears divided over Cruz campaign finance challenge Democrats, poised for filibuster defeat, pick at old wounds  O'Rourke says he raised record .2M since launching campaign for Texas governor MORE ratcheted up his rhetoric against Donald TrumpDonald TrumpKinzinger welcomes baby boy Tennessee lawmaker presents self-defense bill in 'honor' of Kyle Rittenhouse Five things to know about the New York AG's pursuit of Trump MORE on Monday, suggesting his Republican presidential rival's "entire campaign is built on a lie" amid similarly harsh rhetoric from the businessman.

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"Every time Donald gets scared, he begins lashing out, he begins attacking, he begins insulting, he begins yelling, often he begins cursing," the Texas senator said during an interview with Wolf Blitzer broadcast Monday evening on CNN. "I will say this: Donald's campaign, his entire campaign is built on a lie."

Cruz went on to acknowledge that many of those supporting Trump see him as a political outsider but argued, "If you're fed up with Washington, with the corruption of Washington, then it doesn't make any sense to support Donald Trump, who has been enmeshed in the corruption of Washington.

"The lie behind Donald's campaign is that he will stand up to Washington. He is the system," Cruz continued. "Donald Trump and Hillary ClintonHillary Diane Rodham ClintonThe dangerous erosion of Democratic Party foundations The Hill's Morning Report - Presented by Facebook - Democrats see victory in a voting rights defeat Left laughs off floated changes to 2024 ticket MORE are flip sides of the same coin: Donald Trump has made billions buying influence in Washington; Hillary Clinton has made millions selling influence in Washington."

The remarks came after CNN played comments from Trump over the weekend in which he blasted Cruz for formerly being a "citizen of Canada,” repeatedly referring to the Texas senator as "lying Ted."

"One of the biggest liars I've ever seen in my life, I really mean it," Trump said. 

Cruz pushed back during his CNN interview, knocking Trump on eminent domain and also accusing him and Democratic front-runner Hillary Clinton of "empty campaign rhetoric" in their respective remarks on Israel earlier in the day, including Trump's promise of moving the U.S. Embassy from Tel Aviv to Jerusalem. 

Cruz, who is running second to Trump in the delegate count, is aiming to deny the businessman the needed 1,237 delegates to lock up the nomination before the party's convention in July.

He insisted to CNN he had "zero interest whatsoever" in being Trump's running mate, saying it would be a "disaster" if Trump were the nominee, predicting a defeat to Clinton.

He also went after President ObamaBarack Hussein ObamaDemocrats make final plea for voting rights ahead of filibuster showdown Biden nominates Jane Hartley as ambassador to UK To boost economy and midterm outlook, Democrats must pass clean energy bill MORE on the day he met with Cuban President Raúl Castro, charging, "As Barack Obama is there sipping mojitos with brutal communist dictators, he can't be bothered to meet the dissidents."

Also in his interview, Cruz defended Frank Gaffney, his controversial newly named foreign policy adviser who questioned President Obama's birthplace, whom Cruz described as "someone I respect" and a "serious thinker."