Sen. Lindsey GrahamLindsey Olin GrahamGraham's COVID-19 'breakthrough' case jolts Senate Graham says he has COVID-19 'breakthrough' infection Graham, Cuellar press Biden to name border czar MORE said John Kasich is the best Republican presidential candidate but that he can't win the nomination, which is why the South Carolina Republican is backing Ted CruzRafael (Ted) Edward CruzUp next in the culture wars: Adding women to the draft Biden's bipartisan deal faces Senate gauntlet 228 Republican lawmakers urge Supreme Court to overrule Roe v. Wade MORE.

“I think John Kasich would be the best nominee, but he doesn't have a chance,” Graham said during an appearance Thursday on MSNBC's "Morning Joe." 
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“John Kasich's problem is he is an insider in an outsider year and nobody seems to want to buy that,” he added.  

Graham signaled his support for Cruz last week, when news emerged he would be hosting a fundraiser for him. This comes after harsh comments Graham made about his Senate colleague, including while running against the Texas senator in his own White house bid.
 
Graham has argued that while he has differences with Cruz (joking the runner-up in delegates was his "15th choice" in the race), he's the best-positioned Republican other than Donald TrumpDonald TrumpBiden administration to keep Trump-era rule of turning away migrants during pandemic On The Money: Biden, Pelosi struggle with end of eviction ban | Trump attorney says he will fight release of tax returns Lack of transatlantic cooperation on trade threatens global climate change goals MORE.

"I think he'd make a better president than Trump for damn sure, and I think he'd take the country in a new direction other than Clinton," Graham said. 

Asked if Kasich would make a better president than Cruz, Graham said, "I think so." 

He called Trump a "con man" and blasted the GOP front-runner for his support of waterboarding in the wake of this week's terrorist attacks in Brussels. 
 
"I have differences with Ted Cruz that are well known, but I think we share the same political DNA and at the end of the day I think he's a reliable Republican conservative and Mr. Trump is not," Graham said.

Graham predicted that Republicans "probably will" lose in 2016, saying Trump would be defeated by Democratic front-runner Hillary ClintonHillary Diane Rodham ClintonFive things to watch in two Ohio special election primaries Clintons, Stacey Abrams meeting Texas Democrats Biden says Russia spreading misinformation ahead of 2022 elections MORE while Cruz represented "a fighting chance" for Republicans.
 
"I'm not going to stand behind a guy that gets David Duke's support," Graham said of Trump. "So it's no longer about winning the election for me, it's trying to salvage a party that I love and conservatism as I know it."