Democratic presidential hopeful Bernie SandersBernie SandersClyburn: Biden falling short on naming Black figures to top posts Prepare for buyers' remorse when Biden/Harris nationalize health care Biden: 'Difficult decision' to staff administration with House, Senate members MORE won't run as an independent, his wife Jane Sanders said Tuesday, dismissing advice from Republican front-runner Donald TrumpDonald John TrumpUSAID administrator tests positive for COVID-19 Kamala Harris, Stacey Abrams among nominees for Time magazine's 2020 Person of the Year DOJ appeals ruling preventing it from replacing Trump in E. Jean Carroll defamation lawsuit MORE.

"I think we've been very clear right from the beginning that we will not play the role of spoiler," Jane Sanders said on CNN's "Wolf." "Bernie will not be running as an independent."

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Trump earlier Tuesday tweeted that Bernie Sanders "has been treated terribly by the Democrats" in the campaign.

"He should show them, and run as an Independent!" Trump wrote of the Independent senator from Vermont.

Trump himself has repeatedly flirted with an independent bid, warning the GOP to treat him fairly during the primary process. The GOP front-runner appears focused now on fending off a challenge from rivals Ted CruzRafael (Ted) Edward CruzO'Brien on 2024 talk: 'There's all kinds of speculation out there' Ocasio-Cortez, Cruz trade jabs over COVID-19 relief: People 'going hungry as you tweet from' vacation McSally, staff asked to break up maskless photo op inside Capitol MORE and John Kasich, who are coordinating to deny him enough delegates to force a contested Republican National Convention in July.

Asked if she thought Democrats had treated her husband fairly, Jane Sanders said, "Yes, but the process needs to change. We need an open electoral system."

The Sanders campaign has criticized states with closed primaries, arguing they prevented independent voters from showing their support.

Jane Sanders also said that her husband didn't want to splinter Democrats in the November general election.

"We cannot afford a Republican in the White House. We cannot afford a Republican appointing Supreme Court justices," she said.

She insisted that Sanders' "political revolution ... will be a force to be reckoned with" regardless of whether he wins the Democratic nomination.

Bernie Sanders has said any other nominee will need to win over his supporters, giving him leverage.

Hillary ClintonHillary Diane Rodham ClintonFederal workers stuck it out with Trump — now, we're ready to get back to work Biden soars as leader of the free world Intercept DC bureau chief says Biden picks are 'same people' from Obama years MORE, the Democratic front-runner, is favored in polls in several Northeastern states voting Tuesday. She expanded her delegate lead over Sanders by winning New York last week.