Karl Rove on Monday said that a win by Donald TrumpDonald John TrumpNew Bob Woodward book will include details of 25 personal letters between Trump and Kim Jong Un On The Money: Pelosi, Mnuchin talk but make no progress on ending stalemate | Trump grabs 'third rail' of politics with payroll tax pause | Trump uses racist tropes to pitch fair housing repeal to 'suburban housewife' Biden commemorates anniversary of Charlottesville 'Unite the Right' rally: 'We are in a battle for the soul of our nation' MORE in Indiana's Republican presidential primary would ensure that the front-runner will be the party’s nominee.

“If Trump wins — if the NBC/Wall Street Journal/Maris poll is correct — and he wins, the race is effectively over,” Rove said on Fox Business Network’s “Mornings with Maria.”

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“We’ll continue to have some skirmishes in some of the final states, but effectively he’s on the path to 1,237 [delegate] votes and a majority on the first ballot,” the GOP strategist added.

Rove said, however, that both Trump and Sen. Ted CruzRafael (Ted) Edward CruzFiorina: Biden picking Harris for VP 'a smart choice' Russian news agency pushed video of Portland protestors burning a Bible: report After trillions in tax cuts for the rich, Republicans refuse to help struggling Americans MORE (R-Texas) have paths to victory in Indiana on Tuesday.

“My suspicion is that Trump will do well wherever there are Catholics,” he said. "Northeastern Indiana is Catholic.

“Southern Indiana is more probably likely to be good for [Cruz],” Rove added. "It’s settled more by people who came from the South.

“[I’m predicting] Cruz in the south, Trump in the northeast and the winner is the person who sort of takes the center swath of the state.”

Rove and Trump have frequently clashed during the real estate tycoon's presidential campaign.

The GOP strategist said in March, for example, that Trump's grasp of policy issues is "a millimeter deep" and that his negatives are "sky-high" with voters.

Trump, meanwhile, last November called Rove a "biased dope" who had wasted hundreds of millions of dollars on failed political campaigns from other Republicans.

Rove on Monday said that Trump has spent too much energy attacking Cruz and Gov. John Kasich (R-Ohio) during the GOP nominating fight.

“He should be focused on the general election,” he said. "Trump can’t count on the automatic enthusiasm of all Republicans for him as most candidates after heated primaries have been able to do.

“He’s never labored in the vineyards. This is not a guy who has been a life-long Republican. He does not have the base united. This is not a guy who is going to find it easy.”

Trump leads Cruz by over 9 points in Indiana the day before its GOP presidential primary, according to the latest RealClearPolitics average of polls.

Fifty-seven delegates are at stake in Indiana’s primary, including 30 at-large delegates to the statewide winner and 27 by congressional district.

Trump has 996 delegates to Cruz’s 565, according to The Associated Press's delegate tracker. At least 1,237 are necessary for avoiding a contested Republican National Convention in July.