Karl Rove on Monday said that a win by Donald TrumpDonald John TrumpTrump says 'Failing New York Times' should be held 'fully accountable' over Russia report Trump says 'Failing New York Times' should be held 'fully accountable' over Russia report Trump tweets ICE will begin removing 'millions' of undocumented migrants MORE in Indiana's Republican presidential primary would ensure that the front-runner will be the party’s nominee.

“If Trump wins — if the NBC/Wall Street Journal/Maris poll is correct — and he wins, the race is effectively over,” Rove said on Fox Business Network’s “Mornings with Maria.”

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“We’ll continue to have some skirmishes in some of the final states, but effectively he’s on the path to 1,237 [delegate] votes and a majority on the first ballot,” the GOP strategist added.

Rove said, however, that both Trump and Sen. Ted CruzRafael (Ted) Edward CruzOvernight Health Care: Democrats attack after Trump revives talk of ObamaCare replacement | Cruz, Ocasio-Cortez efforts on birth control face major obstacles | CVS investing M to fight teen e-cig use Overnight Health Care: Democrats attack after Trump revives talk of ObamaCare replacement | Cruz, Ocasio-Cortez efforts on birth control face major obstacles | CVS investing M to fight teen e-cig use Biden says he will beat Trump in Texas, Georgia and South Carolina MORE (R-Texas) have paths to victory in Indiana on Tuesday.

“My suspicion is that Trump will do well wherever there are Catholics,” he said. "Northeastern Indiana is Catholic.

“Southern Indiana is more probably likely to be good for [Cruz],” Rove added. "It’s settled more by people who came from the South.

“[I’m predicting] Cruz in the south, Trump in the northeast and the winner is the person who sort of takes the center swath of the state.”

Rove and Trump have frequently clashed during the real estate tycoon's presidential campaign.

The GOP strategist said in March, for example, that Trump's grasp of policy issues is "a millimeter deep" and that his negatives are "sky-high" with voters.

Trump, meanwhile, last November called Rove a "biased dope" who had wasted hundreds of millions of dollars on failed political campaigns from other Republicans.

Rove on Monday said that Trump has spent too much energy attacking Cruz and Gov. John Kasich (R-Ohio) during the GOP nominating fight.

“He should be focused on the general election,” he said. "Trump can’t count on the automatic enthusiasm of all Republicans for him as most candidates after heated primaries have been able to do.

“He’s never labored in the vineyards. This is not a guy who has been a life-long Republican. He does not have the base united. This is not a guy who is going to find it easy.”

Trump leads Cruz by over 9 points in Indiana the day before its GOP presidential primary, according to the latest RealClearPolitics average of polls.

Fifty-seven delegates are at stake in Indiana’s primary, including 30 at-large delegates to the statewide winner and 27 by congressional district.

Trump has 996 delegates to Cruz’s 565, according to The Associated Press's delegate tracker. At least 1,237 are necessary for avoiding a contested Republican National Convention in July.