Former Alaska Gov. Sarah Palin (R) said in an interview to be broadcast Sunday that it was “not a wise decision” for Speaker Paul RyanPaul Davis RyanNo time for the timid: The dual threats of progressives and Trump Juan Williams: Pelosi shows her power Cheney takes shot at Trump: 'I like Republican presidents who win re-election' MORE (R-Wis.) to withhold his support for presumptive Republican presidential nominee Donald TrumpDonald TrumpGOP grapples with chaotic Senate primary in Pennsylvania ​​Trump social media startup receives commitment of billion from unidentified 'diverse group' of investors Iran thinks it has the upper hand in Vienna — here's why it doesn't MORE.

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“His political career is over but for a miracle, because he has so disrespected the American people,” Palin said of Ryan on CNN’s “State of the Union.”

“It kind of screws his chances for the 2020 presidential bid that he’s gunning for,” she said.

Paul, former Republican presidential nominee Mitt Romney’s 2012 running mate, said last Thursday he is “just not ready” to support the real estate mogul.

“I think Paul Ryan is soon to be ‘Cantored,’ as in Eric CantorEric Ivan CantorRepublicans eager to take on Spanberger in Virginia Virginia emerging as ground zero in battle for House majority McAuliffe's loss exposes deepening Democratic rift MORE,” Palin, who ran with John McCainJohn Sidney McCainThe bully who pulls the levers of Trump's mind never learns GOP senators appalled by 'ridiculous' House infighting MSNBC's Nicolle Wallace, Chris Christie battle over Fox News MORE on the Republican ticket in 2008, added. Cantor, the former House majority leader, lost his primary bid in Virginia in 2014.

“I will do whatever I can for Paul Nehlen,” Palin said of Ryan’s primary challenger.

"This man is a hard-working guy, so in touch with the people," Palin added. "Paul Ryan and his ilk, their problem is they have become so disconnected by the people whom they are elected to represent.

"They feel so threatened at this point that their power, their prestige, their purse will be adversely affected by the change that is coming with Trump and with someone like Paul Nehlen, that they're not thinking straight right now."

— This report was updated at 9:00 a.m.