Donald TrumpDonald John TrumpThorny part of obstruction of justice is proving intent, that's a job for Congress Obama condemns attacks in Sri Lanka as 'an attack on humanity' Schiff rips Conway's 'display of alternative facts' on Russian election interference MORE’s presidential campaign is teetering on the edge of implosion over the obscene sexual comments he made about women, with the nominee facing unprecedented calls from Republicans to drop out of the race.

Trump’s late-night apology for the remarks failed to quell the storm over his comments, which were caught on video in 2005 and include a graphic line about grabbing women “by the p---y.”

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The political fallout snowballed on Trump on Saturday, one day before a pivotal second presidential debate against Democrat Hillary ClintonHillary Diane Rodham ClintonThorny part of obstruction of justice is proving intent, that's a job for Congress Nadler: I don't understand why Mueller didn't charge Donald Trump Jr., others in Trump Tower meeting Kellyanne Conway: Mueller didn't need to use the word 'exoneration' in report MORE that is expected to draw tens of millions of viewers.

Republicans in the House and Senate are abandoning Trump in droves, with many retracting their endorsements or urging him to leave the ticket altogether for the good of the party.

Sen. John ThuneJohn Randolph ThuneTelehealth is calling — will Congress pick up? GOP grows tired of being blindsided by Trump Hillicon Valley: Assange faces US charges after arrest | Trump says WikiLeaks 'not my thing' | Uber officially files to go public | Bezos challenges retail rivals on wages | Kremlin tightens its control over internet MORE (R-S.D.), the third ranking Republican in the Senate, on Saturday became the latest GOP official to call on Trump to withdraw.

Mike PenceMichael (Mike) Richard PencePence: Mueller report confirms 'no collusion, no obstruction' Melania Trump, Karen Pence say they're ready to serve four more years in White House The Turkish rupture could cause a fissure in NATO MORE should be our nominee effective immediately,” Thune tweeted.

The exploding controversy has thrown Republicans up and down the ballot into crisis mode and has put party in a desperate position as it seeks to maintain its majority in the Senate just one month before Election Day.

“I can no longer look past this pattern of behavior and inappropriate comments from Donald Trump,” Rep. Joe Heck (R-Nev.), who is in a tight race for Nevada Senate, told supporters at a rally with Mitt Romney on Saturday. “My wife, my daughters, my mother, my sister and all women deserve better. The American people deserve better.”

Trump has been defiant in the face of growing calls for him to step aside, saying there is “zero chance” that he will back out of the race.

“I’d never withdraw,” Trump said in an interview with the Washington Post. “I’ve never withdrawn in my life. No, I’m not quitting this race. I have tremendous support.”

Instead, Trump is vowing to redouble his attacks against Clinton for the way she treated the women who had affairs with Bill ClintonWilliam (Bill) Jefferson ClintonThorny part of obstruction of justice is proving intent, that's a job for Congress 20 years after Columbine: What has changed? Impeachment? Not so fast without missing element of criminal intent MORE or accused him of sexual assault —  a course of action Republicans have warned him against.

The seismic controversy has thrust Pence into a difficult spot.

The vice presidential candidate rebuked his running mate on Saturday, and said he is praying for Trump and his family during this difficult time.

“As a husband and father, I was offended by the words and actions described by Donald Trump in the eleven-year-old video released yesterday,” Pence said in a statement. “I do not condone his remarks and cannot defend them.”

Pence said he looks forward to Trump taking the opportunity at Sunday night’s debate to “show what is in his heart.”

The Indiana governor had tentatively planned to replace Trump at a joint appearance with Speaker Paul RyanPaul Davis RyanAppeals court rules House chaplain can reject secular prayers FEC filing: No individuals donated to indicted GOP rep this cycle The Hill's Morning Report - Waiting on Mueller: Answers come on Thursday MORE (R-Wis.) at a campaign event in Wisconsin on Saturday, but has pulled out at the last minute.

Ryan was scheduled to make his campaign appearance with Trump at an event meant to show party unity on Saturday, but he has disinvited the GOP nominee amid the uproar.

Ryan and other top GOP leaders in Congress are furious with Trump, both for his remarks and his handling of the fallout.

In the early hours following the breaking news, they made clear in a string of blistering statements that they did not believe Trump had adequately apologized.

Asked whether Ryan was swayed by Trump’s apology, a source familiar with the Wisconsin Republican’s thinking responded, “That’s for the voters to decide.”

“Mr. Trump said he plans to talk about this at the debate and so we'll see what more he has to say," added the source.

Some, such as Sen. Mark KirkMark Steven KirkThe global reality behind 'local' problems Dems vow swift action on gun reform next year This week: Trump heads to Capitol Hill MORE (R-Ill.), have called for Trump to be forcibly removed from the ticket, although it is likely too late to do so.

Rather, there will be growing calls for the Republican National Committee to pull its support for Trump and batten down the hatches around protecting the party’s majorities in the House and Senate.

The RNC has so far swatted away speculation that it would consider cutting Trump loose.

Trump is running a bare-bones campaign that is overly reliant on staff from the RNC, and a reallocation of resources to down-ballot races would effectively doom his campaign.

Until then, down-ballot Republicans have begun signaling they’ll be run parallel campaigns that are untethered from the GOP nominee; leaving the party in a terrible position just over a month before Election Day.

Vulnerable Republicans running for Senate – Sens. Kelly AyotteKelly Ann AyotteSchultz recruiting GOP insiders ahead of possible 2020 bid Bottom Line US, allies must stand in united opposition to Iran’s bad behavior MORE (R-N.H.), Richard BurrRichard Mauze BurrGOP senator: 'No problem' with Mueller testifying Collins backs having Mueller testify Graham says he's 'not interested' in Mueller testifying MORE (R-N.C.) and Mark Kirk (R-Ill.) among them – were quick to register their disgust with the party’s nominee.

“I have reached the decision that I can no longer endorse Donald Trump,” Idaho Sen. Mike CrapoMichael (Mike) Dean CrapoGraham says he's 'not interested' in Mueller testifying Senate needs to stand up to Trump's Nixonian view of the Fed Senate bill seeks to bring freedom back to banking MORE said in a statement.

“I urge Donald Trump to step aside and allow the Republican Party to put forward a conservative candidate like Mike Pence who can defeat Hillary Clinton.”