Donald TrumpDonald John TrumpDavid Axelrod after Ginsburg cancer treatment: Supreme Court vacancy could 'tear this country apart' EU says it will 'respond in kind' if US slaps tariffs on France Ginsburg again leaves Supreme Court with an uncertain future MORE cut in with the most personal line of Wednesday night’s presidential, describing Hillary ClintonHillary Diane Rodham ClintonTrump takes aim at media after 'hereby' ordering US businesses out of China Trump knocks news of CNN hiring ex-FBI official McCabe Taylor Swift says Trump is 'gaslighting the American public' MORE as a "nasty woman."

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The exchange came during a discussion of economic plans. Clinton was speaking about her commitment to "raise taxes on the wealthy" when she took a shot at Trump over his attempts to avoid paying taxes. 

"My Social Security payroll contribution will go up," Clinton said, "as will Donald's, assuming he can't figure out how he can get out of it."

"Such a nasty woman," Trump said in response, shaking his head and holding up his finger at Clinton.