Donald TrumpDonald TrumpCaitlyn Jenner on Hannity touts Trump: 'He was a disruptor' Ivanka Trump doubles down on vaccine push with post celebrating second shot Conservative Club for Growth PAC comes out against Stefanik to replace Cheney MORE cut in with the most personal line of Wednesday night’s presidential, describing Hillary ClintonHillary Diane Rodham ClintonPelosi's archbishop calls for Communion to be withheld from public figures supporting abortion rights Hillary Clinton: Biden less 'constrained' than Clinton and Obama due to prior administration Biden's unavoidable foreign policy crisis MORE as a "nasty woman."

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The exchange came during a discussion of economic plans. Clinton was speaking about her commitment to "raise taxes on the wealthy" when she took a shot at Trump over his attempts to avoid paying taxes. 

"My Social Security payroll contribution will go up," Clinton said, "as will Donald's, assuming he can't figure out how he can get out of it."

"Such a nasty woman," Trump said in response, shaking his head and holding up his finger at Clinton.