GOP senators: We could work with Hillary Clinton
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Sen. Johnny IsaksonJohnny IsaksonLoeffler paints herself as 'more conservative than Attila the Hun' in new campaign ad Georgia GOP Senate candidates cite abortion in pushing Ginsburg replacement Loeffler: Trump 'has every right' to fill Ginsburg vacancy before election MORE (R-Ga.) is predicting that congressional Republicans will be more willing to work with Hillary ClintonHillary Diane Rodham ClintonButtigieg stands in as Pence for Harris's debate practice Senate GOP sees early Supreme Court vote as political booster shot Poll: 51 percent of voters want to abolish the electoral college MORE than they have been with President Obama, should she be elected president.  

"Barack ObamaBarack Hussein ObamaMichelle Obama and Jennifer Lopez exchange Ginsburg memories Pence defends Trump's 'obligation' to nominate new Supreme Court justice The militia menace MORE was somewhat of an unknown – he was a senator, but only for a year-and-a-half before he was elected president. She is a known commodity, and I think there’ll be more camaraderie in terms of working together, than there might have been in the early days of Obama," Isakson told the Atlanta Journal Constitution. 
 
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Democrats have repeatedly blasted Republican tactics under the Obama administration, arguing that GOP senators have reached a record level of obstruction on legislation and nominations. 
 
Retiring Senate Minority Leader Harry ReidHarry Mason ReidThe Supreme Court vacancy — yet another congressional food fight Trump seeks to turn around campaign with Supreme Court fight On The Trail: Battle over Ginsburg replacement threatens to break Senate MORE (D-Nev.) took a final pre-election swing at Republicans from the Senate floor last month, saying lawmakers had treated Obama with "unprecedented disrespect." 
 
Isakson's comments come as Clinton has narrowly trailed Trump in the typically red state, feeding Democrats hopes of expanding the electoral map. According a RealClearPolitics average of polls, the GOP presidential nominee is leading by less than 5 points. 
 
The Georgia Republican isn't the only one who is open to collaborating with a hypothetical Clinton administration, even though multiple congressional committees are still probing her time atop the State Department. 
 
Sen. Lindsey GrahamLindsey Olin GrahamSenate GOP aims to confirm Trump court pick by Oct. 29: report The Hill's Campaign Report: GOP set to ask SCOTUS to limit mail-in voting Senate GOP sees early Supreme Court vote as political booster shot MORE (R-S.C.) said Clinton would find a "willing partner" on immigration reform, bolstering the military and a Simpson-Bowles-type of initiative to improve federal spending, should she win. 
 
"I can do two things at once. I can criticize and I can cooperate," he told The Hill last month. "I don't see that they're inconsistent." 
 
Sen. John CornynJohn CornynThe Hill's Campaign Report: GOP set to ask SCOTUS to limit mail-in voting Liberal super PAC launches ads targeting vulnerable GOP senators over SCOTUS fight Senate GOP faces pivotal moment on pick for Supreme Court MORE (R-Texas)—while stressing that he doesn't believe Clinton will win in November—said Americans expect GOP senators to work with whoever is in the White House. 
 
"We'll do our duty, you know regardless of who is president," the Senate's No. 2 Republican told The Hill last week. "The people we serve want us to to work together for their benefit so that's certainly my posture." 
 
Cornyn declined to name specific issues that he believes he and Clinton could work well together on. 
 
Republicans are defending 24 Senate seats in November, including a handful in purple states previously carried by President Obama. They will lose control of the Senate if Democrats net five Senate seats, or four if Clinton also wins the White House.