Sen. Mary Landrieu (D-La.) will "definitely" run for reelection in 2014, she told the New Orleans Times-Picayune.

"I am definitely running for re-election," Landrieu said Baton Rouge on Monday. "My numbers are moving in the right direction."

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This is good news for Democrats: Landrieu is by far their best chance to hold onto the seat. But she is expected to face a tough challenge in the rapidly Republican-trending state.

While then-President Clinton won Louisiana twice in the 1990s it has moved quickly to the GOP: President Obama lost the state by a 19-point margin in 2008 and Republicans have won almost every statewide race in the last few electoral cycles. Landrieu is the last prominent Democrat to hold statewide office. In 2008, a very good year for Democrats nationally, Landrieu won reelection with 52 percent of the vote.

Rep. Bill Cassidy (R-La.) is rumored to be interested in the race.