Five senators up for reelection in 2014 bucked their parties in the Senate’s procedural vote on gun control Thursday.

Both Democrats who voted against the motion face reelection next year in states President Obama lost in the 2012 presidential election: Sens. Mark BegichMark Peter BegichAlaska political mess has legislators divided over meeting place Former GOP chairman Royce joins lobbying shop Lobbying world MORE (Alaska) and Mark PryorMark Lunsford PryorTom Cotton's only Democratic rival quits race in Arkansas Medicaid rollback looms for GOP senators in 2020 Cotton pitches anti-Democrat message to SC delegation MORE (Ark.).

Three of the 16 Republicans who voted in favor of the motion face reelection next year: Sens. Susan CollinsSusan Margaret CollinsThe Hill's Morning Report — Sponsored by AdvaMed — House panel delays impeachment vote until Friday Senate gears up for battle over witnesses in impeachment trial McConnell: I doubt any GOP senator will vote to impeach Trump MORE (Maine), Lindsey GrahamLindsey Olin GrahamTrump: 'I wouldn't mind' a long Senate impeachment process Poll finds Graham with just 2-point lead on Democratic challenger Hill editor-in-chief calls IG report 'a game-changer' MORE (S.C.) and Lamar AlexanderAndrew (Lamar) Lamar AlexanderTrump scramble to rack up accomplishments gives conservatives heartburn Overnight Health Care — Presented by That's Medicaid — Turf war derails push on surprise medical bills | Bill would tax e-cigarettes to pay for anti-vaping campaign | .5M ad blitz backs vulnerable Dems on drug prices Turf war derails bipartisan push on surprise medical bills MORE (Tenn.).

ADVERTISEMENT
Wednesday’s motion was a procedural vote that doesn’t even formally begin debate on the gun control measure, but it was still a politically touchy vote.

President Obama and gun control advocates pressed for the vote, while the National Rifle Association warned it would negatively score the votes of any senator who voted to proceed on the issue.

Democrats up for reelection in red states next year who voted with their party and against the NRA include Sens. Mary LandrieuMary Loretta LandrieuCongress needs to work to combat the poverty, abuse and neglect issues that children face Dems wrestle over how to vote on ‘Green New Deal’ Lobbying world MORE (La.), Kay HaganKay Ruthven HaganGOP braces for Democratic spending onslaught in battle for Senate Democrats will win back the Senate majority in 2020, all thanks to President Trump The Hill's Morning Report - Presented by Better Medicare Alliance - Dems shift strategy on impeachment vote MORE (N.C.) and Max BaucusMax Sieben BaucusBottom line Overnight Defense: McCain honored in Capitol ceremony | Mattis extends border deployment | Trump to embark on four-country trip after midterms Congress gives McCain the highest honor MORE (Mont.).

Sens. Marco RubioMarco Antonio RubioWhite House makes push for paid family leave and child care reform Tom Hanks weighs in on primary: 'Anybody can become president' GOP senator blocks bill aimed at preventing Russia election meddling MORE (Fla.) and Rand PaulRandal (Rand) Howard PaulPentagon to take bigger role in vetting foreign students after Pensacola shooting Overnight Defense: House passes compromise defense bill | Turkey sanctions advance in Senate over Trump objections | Top general says military won't be 'raping, burning and pillaging' after Trump pardons Rand Paul: 'We need to re-examine' US-Saudi relationship after Florida shooting MORE (Texas) both carried through on their promise to vote against the motion. Both are possible presidential contenders in 2016, and their votes against the motion could fire up GOP primary voters.

Though in a general election, the votes against moving toward a debate on gun control could open them up to attacks.

Both Democrats who voted with the NRA are top political targets for Republicans.

A recent poll funded by the Club for Growth found Pryor behind potential challenger Rep. Tom CottonThomas (Tom) Bryant CottonTikTok chief cancels Capitol Hill meetings, inflaming tensions Lawsuits pose new challenge for TikTok TikTok's leader to meet with lawmakers next week MORE (R ) by 10 percentage points.

In Alaska, polls suggest Begich is vulnerable, and he already has one prominent potential opponent in Lt. Gov. Mead Treadwell, who recently opened an exploratory committee to look into a bid.

Landrieu is also considered vulnerable but has exhibited a willingness to buck the red-state Democratic trend of showing independence by voting against her party on controversial measures.

On Thursday, she reported raising $1.2 million in the first quarter, which may be boosting her confidence. On the GOP side, Collins is running in a state easily won in 2012 by Obama and where legislators are considering a suite of gun control bills. The president's advocacy arm, Organizing for Action, has targeted her with ads on gun control.

Alexander's vote indicates he feels safe. Though he initially looked vulnerable to a primary challenge, the senator roped nearly the entire Tennessee delegation into his reelection campaign.

No strong candidates have emerged yet to take on Graham, either. He’s repeatedly shown he’s not afraid to vote against conservatives, and he criticized Paul’s recent filibuster on U.S. drone policy.