GOP hopes for winning back the Senate rest on Arkansas, where Rep. Tom CottonTom Bryant CottonSenate mulls changes to .9 trillion coronavirus bill Trump seeks to cement hold on GOP Sunday shows preview: 2024 hopefuls gather at CPAC; House passes coronavirus relief; vaccine effort continues MORE (R) is running to unseat Sen. Mark PryorMark Lunsford PryorEverybody wants Joe Manchin Cotton glides to reelection in Arkansas Live updates: Democrats fight to take control of the Senate MORE, widely seen as the most vulnerable Democrat running in 2014. [WATCH VIDEO]

A Cotton victory over Pryor would open the door for Republicans to win the six seats they need to control the upper chamber.

But if Pryor survives, the GOP’s hopes of taking over the Senate will all but evaporate.

“There really is no path to the majority that doesn't include Arkansas,” one national Republican strategist told The Hill. “It's hard to imagine that we'd lose that seat and win in North Carolina, Louisiana and Alaska. That'd be tough.”

Those states are the homes of the three other most vulnerable Democrats running next year — but none are seen to be in as much trouble as Pryor.

President Obama won just 37 percent of the state’s vote in 2012, and Pryor is the last Democrat left standing in his state’s congressional delegation. Sen. Blanche Lincoln (D-Ark.) lost overwhelmingly in 2010 to then-Rep. John BoozmanJohn Nichols BoozmanPassage of the John Lewis Voting Rights Advancement Act is the first step to heal our democracy On The Trail: Trump threatens a Tea Party redux Managers seek to make GOP think twice about Trump acquittal MORE (R-Ark.) months after voting, like Pryor, for ObamaCare’s passage.

A series of polls released in recent days suggests a close race between Pryor and Cotton, who formally launched his campaign Tuesday.

Yet all show Pryor topping out with 43 percent support, a dangerously low number for an incumbent. Republicans are confident in Cotton and appear to already be sizing up Pryor’s office. But the incumbent says he’s not scared of a challenge, noting he’s been written off before.

“The most vulnerable label — they talked about that in 2002 when I ran; they said I couldn't win,” Pryor told The Hill in an interview.

“In 2008, I was a one-term wonder, and then I won with almost 80 percent of the vote,” he added. People who say he’s the most vulnerable Senate Democrat running for reelection “do not understand Arkansas politics,” Pryor said.

“We've heard that from Washington for years. It doesn't faze me. It doesn't bother me," he said. "If I was so vulnerable, why would they be spending all this outside money against me?” 

Republicans say Pryor should be seen as vulnerable.

“An incumbent U.S. senator whose reelect number is between 35 and 43 percent is in deep trouble,” said Arkansas Republican Party spokesman David Ray. “There's no way you can church that up. There's no way you can sugarcoat that.

“There's no question this will be a hard-fought race,” Ray continued. “It's still early in the race. It's yet to really take shape, but the preliminary signs show we have an excellent opportunity, and we're going to have the best possible candidate.”

Republicans say the unpopularity of Democrats up and down the ballot and Cotton’s impressive resume as a former Army ranger will help him win comfortably.

Democrats predict Pryor’s independent streak and strong family name, coupled with Cotton’s very conservative voting record and relative inexperience with running tough races, will help Pryor pull off a narrow win.

Pryor, who in the interview acknowledged the race would be a hard one, is already airing ads blasting Cotton as a political opportunist out of step with Arkansas voters. Arkansas’s Democratic Party also has launched a website attacking Cotton’s voting record.

Outside groups have already spent more than $1.2 million attacking Pryor. Conservatives have tied him to Obama, while gun control groups have criticized his vote against background check legislation. Nonpartisan observers predict a close race.

“This race will get framed either as a referendum on Mark Pryor as Barack ObamaBarack Hussein ObamaCPAC, all-in for Trump, is not what it used to be Americans have decided to give professionals a chance Artist behind golden Trump statue at CPAC says he made it in Mexico MORE, or a referendum on whether Cotton is too extreme to get elected,” said Roby Brock, the editor of the state-based political website Talk Business.

He expects the race to go down to the wire.

“The negatives are what's going to win out,” he said.