Republican strategist Karl Rove said on "Fox News Sunday" that Sen. Lisa MurkowskiLisa Ann MurkowskiSenate confirms Radhika Fox to lead EPA's water office Democrat presses Haaland on oil and gas review Hundreds in West Virginia protest Manchin's opposition to voting rights legislation MORE (R-Alaska) is going to lose her Senate bid and that her decision to wage a write-in candidacy is “sad and sorry.”

“Absolutely no she can't win,” Rove said. “Under the law, you have to carefully spell the name exactly correct, now everyone go to your pencil and paper and write the name 'Murkowski' and see if you got it right.

"No, she’s going to lose," he said.

"Now, the bigger, more important question is is she going to keep a Republican from winning," with her write-in bid, he said. "Who would have thought that one of the most conservative states in the country ran the risk of having two liberal Democrats who follow the Obama line representing it in the United States Senate? And that's what she could do as a spoilsport."

Rove also pressed former Alaska Gov. Sarah Palin to go and campaign for “her favorite Christine O’Donnell,” the Tea Party candidate who had a stunning win in the Delaware Republican primary. O’Donnell canceled her appearances on "Fox News Sunday" and "Face the Nation" on account that she was exhausted and wanted to focus on her state campaign.

Rove and O’Donnell have traded barbs recently. Rove has strongly opposed O’Donnell and said that she is not electable, and needs to explain controversies from her past.

Because Palin boosted O’Donnell’s campaign, Rove urged Palin on Sunday to go campaign in Delaware and bring O’Donnell “to the finish line,” if she wanted to “demonstrate her political power.”