"I'm confident we're going to get some delegates. That, of course, is what this is all about — getting the delegates necessary to become the nominee. But getting the majority of the delegates, that would be icing on the cake," Romney said.

A surprise win in either of the states could provide a knockout blow to Newt Gingrich, a persistent antagonist for Romney throughout the campaign. Gingrich's campaign spokesman, R.C. Hammond, told reporters Wednesday that the Deep South contests were "must-wins."

Romney is still without a win in the region, with Gingrich taking contests in South Carolina and Georgia and Rick Santorum winning Tennessee.