Ryan: 'We are at war with Islamist terrorists'
© Greg Nash

Speaker Paul Ryan (R-Wis.) issued a statement Sunday evening on the shooting at an Orlando, Fla., nightclub that killed 50 and injured 53 more.

The FBI conducted three interviews with Omar Mateen, the 29-year-old man suspected in the deadliest mass shooting in U.S. history, after he made "inflammatory comments to coworkers alleging possible terrorist ties."

"As we heal, we need to be clear-eyed about who did this," Ryan said in the statement. "We are a nation at war with Islamist terrorists. Theirs is a repressive, hateful ideology that respects no borders. It is a threat to our people at home and abroad. Our security depends on our refusal to back down in the face of terror. We never will."

Mateen pledged allegiance to the Islamic State in Iraq and Syria (ISIS) before carrying out the assault, reportedly with an AR 15-style assault rifle and a handgun. ISIS claimed responsibility for the attack, saying over an encrypted phone that it was carried out by one of its fighters.

President Obama, in a statement from the White House issued Sunday afternoon, called it an "act of terror and an act of hate." The killings took place at Pulse, a gay nightclub, during Pride Month. 

Obama also vowed a full investigation of the attack and canceled a planned campaign event in Wisconsin on Wednesday with Hillary ClintonHillary Diane Rodham ClintonQueer Marine veteran launches House bid after incumbent California Rep. Susan Davis announces retirement Poll: Trump neck and neck with top 2020 Democrats in Florida Former immigration judge fined, temporarily banned from federal service for promoting Clinton policies MORE, the presumptive Democratic nominee for president.

Donald Trump, the presumptive Republican nominee, ripped Obama for not calling it an act of radical Islamic terrorism.

Ryan refrained from criticism of Obama in his statement but said the U.S. was at war with Islamic terrorism.