Sen. Marco RubioMarco Antonio RubioHow a nice-guy South Dakota senator fell into a Trump storm Republicans threaten floor takeover if Democrats weaken filibuster  Democrats must close the perception gap MORE (R-Fla.) on Sunday avoided directly saying whether he'd trust presumptive Democratic presidential nominee Hillary ClintonHillary Diane Rodham ClintonA year into his presidency, Biden is polling at an all-time low The Memo: 2024 chatter reveals Democratic nervousness Second gentleman Emhoff acts as public link to White House MORE with the nuclear codes.

"Once you assume the office, no matter who holds that office, I think that the reality and the gravity of it always weighs on these people," Rubio said on CBS's "Face The Nation."

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"It's a very difficult issue to face. So I would hope that I can trust no matter who wins with the nuclear codes."

The Florida senator has said previously he doesn't think presumptive GOP presidential nominee Donald TrumpDonald TrumpWendy Sherman takes leading role as Biden's 'hard-nosed' Russia negotiator Senate needs to confirm Deborah Lipstadt as antisemitism envoy — Now Former acting Defense secretary under Trump met with Jan. 6 committee: report MORE could be trusted with the nuclear codes.

He said on Sunday that it is important to look at the kind of foreign policy Clinton would pursue and where that would lead the country.

"This is a person who has generally supported virtually all of the Obama agenda," he said.

Rubio continued to slam several of the foreign policy decisions Clinton has supported, referencing the reset with Russia and the Iran nuclear deal. But the senator still did not say directly whether he'd trust Clinton with the nuclear codes.

"Here's a better approach: And that is ensuring that we have a foreign policy to ensure that we never reach a point where something like that could actually happen, where nuclear weapons would have to be used," he said, "which in my mind obviously is the worst and most apocalyptic scenario possible."