Sen. Lindsey GrahamLindsey Olin GrahamWhite House won't move forward with billions in foreign aid cuts GOP group calls on Republican senators to stand up to McConnell on election security in new ads Cindy McCain says no one in Republican Party carries 'voice of reason' after husband's death MORE (R-S.C.) joked that Wednesday's first Democratic presidential debate made a third term for President TrumpDonald John TrumpDavid Axelrod after Ginsburg cancer treatment: Supreme Court vacancy could 'tear this country apart' EU says it will 'respond in kind' if US slaps tariffs on France Ginsburg again leaves Supreme Court with an uncertain future MORE look "better and better."

“After tonight’s #DemocraticDebate.......that whole Trump 3rd term thing is looking better and better,” Graham tweeted Wednesday night.

By Thursday, #LindseyGrahamResign began trending on Twitter, with hundreds urging the senator to step down.

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“Third term for Trump you have lost your mind [and] now you need to lose your seat,” one user tweeted, while another user called Graham, a frequent defender of Trump, an “absolute loser.”

Jaime Harrison, the former chairman of South Carolina’s Democratic Party who is challenging Graham in 2020, blasted Graham on Thursday, tweeting: “Senator Graham, in SC we have spines. Do us a favor and find yours.”

“When your only concern is covering your political ass — you joke about undermining the US Constitution, sell out your constituents, and abandon your moral compass,” Harrison wrote.

#LindseyGrahamResign also trended in May, when Graham, the Senate Judiciary Committee chairman, said Trump’s son, Donald Trump Jr.Donald (Don) John TrumpSarah Huckabee Sanders becomes Fox News contributor PETA billboard in Baltimore calls Kushner a 'rich pest' Dick Cheney to attend fundraiser supporting Trump reelection: report MORE, should refuse to answer questions from the Senate Intelligence Committee, which subpoenaed him to testify about his communication with Russian officials.

“You just show up and plead the Fifth and it’s over with,” Graham said.