Texas Sen. Ted CruzRafael (Ted) Edward CruzWhite House denies pausing military aid package to Ukraine Ted Cruz says critical race theory is as racist as 'Klansmen in white sheets' Pentagon pulling 'certain forces and capabilities,' including air defenses, from Middle East MORE (R) hit back at Chicago Mayor Lori LightfootLori LightfootChicago mayor defends her decision to grant interviews exclusively to people of color Daily Caller sues Chicago mayor for limiting interviews to people of color Tulsi Gabbard on Chicago mayor's decision to limit media interviews to people of color: 'Anti-white racism' MORE (D) Tuesday after she told the senator to “keep our name out of your mouth.”

Lightfoot took aim at Cruz late Monday after the senator had used an uptick in weekend violence in Chicago as an example to argue that “gun control doesn’t work.”

Cruz responded Tuesday by saying that "your anger is misplaced" and linking to a USA Today story showing that Chicago had the most homicides among U.S. cities last year, though Baltimore had the highest murder rate per capita. 

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“Mayor, your anger is misplaced. Virtually every year, Chicago has the most murders of any city in America.  In 2017, the top five were: Chicago (650 murders), Baltimore (343), Philadelphia (317), New York (290), and Los Angeles (286),” Cruz said in his tweet.

Lightfoot on Monday had argued that "60% of illegal firearms recovered in Chicago come from outside IL—mostly from states dominated by coward Republicans like you who refuse to enact commonsense gun legislation."

"Keep our name out of your mouth," she added.

In another tweet, Cruz argued that "All five of those cities have had Democratic mayors for decades and aggressive gun control policies—none seems to be working," though both New York and Los Angeles have had Republican mayors within the last two decades, including former Mayors Rudy GiulianiRudy GiulianiCourt sets Smartmatic dismissal date on Giuliani, Bartiromo, others Ukraine sanctions two businessmen tied to Giuliani Mo Brooks accuses Swalwell attorney who served papers on his wife of trespassing MORE and Michael BloombergMichael BloombergPress: Even Jeff Bezos should pay income taxes What the Democrats should be doing to reach true bipartisanship 5 former Treasury secretaries back Biden's plan to increase tax enforcement on wealthy MORE for a period before he became independent. 

“But Chicago’s murder totals are often DOUBLE the next closest city. So how do you explain the big cities in red states, without aggressive gun control laws, where murder rates are MUCH lower than Chicago?” Cruz also tweeted.

"Maybe, rather than getting angry when others point out the tragically high murder rate in Chicago, you put aside the partisan talking points & the failed gun-control policies Chicago has pursued for decades," Cruz continued.

The spat between Cruz and Lightfoot began when the Texas senator on Monday tweeted criticism of Chicago officials for their gun control policies, as politicians have spoken out in the wake of the mass shooting in West Texas on Saturday that killed seven people and injured 22. 

“Look at Chicago. Disarming law-abiding citizens isn’t the answer. Stopping violent criminals—prosecuting & getting them off the street—BEFORE they commit more violent crimes is the most effective way to reduce murder rates. Let’s protect our citizens,” Cruz wrote.