Speaker Nancy Pelosi (D-Calif.) doesn't have much patience for conservative claims that an individual healthcare mandate is unconstitutional.

Pressed on the issue by a reporter from a conservative website, Pelosi shot back: "Are you serious? Are you serious?"

Listen to the exchange below:

As background, some conservatives claim that it is unconstitutional for the federal government to demand that individuals purchase health insurance. Those who say the mandate is constitutional point to the Commerce Clause, which allows the federal government to regulate interstate commerce. 

Read Timothy's Noah piece at Slate for a rundown of the debate.