Brown crossed the aisle after Majority Leader Harry ReidHarry Mason ReidHarry Reid: Biden should give GOP three weeks to see if they will work with him Democrats to boycott committee vote on Amy Coney Barrett's Supreme Court nomination Durbin says he will run for No. 2 spot if Dems win Senate majority MORE (D-Nev.) nixed an $85 billion, bipartisan plan in favor of a more narrowly-focused bill.

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“I came to Washington to be an independent voice, to put politics aside, and to do everything in my power to help create jobs for Massachusetts families," Brown said in a statement. "This Senate jobs bill is not perfect. I wish the tax cuts were deeper and broader, but I voted for it because it contains measures that will help put people back to work."

Democrats needed to poach Brown and and least one other Republican to reach the 60 votes necessary. Centrist Republican Sens. Susan CollinsSusan Margaret CollinsTrump expressed doubt to donors GOP can hold Senate: report Murkowski says she will vote to confirm Barrett to Supreme Court on Monday Biden's oil stance jars Democrats in tough races MORE (Maine) and Olympia Snowe (Maine) also voted for cloture on the proposal. 

Reitiring GOP Sens. George Voinovich (Ohio) and Kit Bond (R-Mo.) also voted for cloture.

Brown was elected to the Senate with the backing of conservatives largely because of his pledge to serve as the 41st vote to uphold a filibuster of the Democrats health reform bill.

But Brown has expressed a willingness to work with Democrats on other issues.