Sen. Chuck Grassley (R-Iowa) said Monday he is wary of working with Democrats on major legislation in the aftermath of the healthcare debate.

As ranking member of the Senate Finance Committee, Grassley negotiated a healthcare last year with chairman Max Baucus (D-Mont.) and four other bipartisan lawmakers for about three months.

But after negotiations reached an impasse, Democrats decided to go it alone and eventually passed a bill into law.

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"I'm a little anxious about bipartisanship when you get treated the way we were treated on healthcare," he said on a conference call with Iowa reporters.

Grassley joins other Republican lawmakers who have worked with Democrats in the past in expressing doubts about reaching across the aisle. 

Democrats accused Republicans of stalling the process and not wanting to earnestly support the bill in defending their decision to go it alone.

Sen. John McCain (R-Ariz.) last week said that the GOP won't cooperate with Democrats for the rest of the year, saying that the party "poisoned the well" by passing healthcare on a partisan basis. McCain, who penned a campaign finance law with Sen. Russ Feingold (D-Wis.) in 2002, later backed away slightly from that position.

Sen. Lindsey Graham (R-S.C.), who has recently worked with Democrats and the White House on immigration reform and terror trials, said that immigration is "dead" in the Senate this year. 

Like other Republicans, the Iowa senator said he favors "repeal and replace" for the healthcare law.

Grassley added that Senate Majority Leader Harry Reid's (D-Nev.) decision to ax a bipartisan jobs bill that Baucus and he negotiated in favor of a pared-down plan irked him.

"That's a knife in the back," Grassley said.