Republicans expect at least "big changes" to the new health reform law as a result of their efforts, Sen. Lamar AlexanderLamar AlexanderMcConnell gets GOP wake-up call The Hill's Morning Report - Presented by Alibaba - Democrats return to disappointment on immigration Authorities link ex-Tennessee governor to killing of Jimmy Hoffa associate MORE (R-Tenn.) said Thursday.

Alexander, the third-ranking Republican member of the Senate, predicted that Republicans would be able to force major changes to the new healthcare system amidst pledges by many GOP candidates that they would seek to repeal the plan in its entirety. 

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The Tennessee Republican said he agreed with President Barack ObamaBarack Hussein ObamaThe Memo: Biden, bruised by Afghanistan, faces a critical test in Ukraine Is the US capable of thinking strategically? Juan Williams: GOP infighting is a gift for Democrats MORE's assertion that the healthcare bill was a proxy for a debate over the role in government in the U.S.

"And that's the debate we're going to have this year, and it's going to define every congressional race," Alexander told the editorial board of the Chattanooga Times Free Press. "I think the healthcare bill will be the biggest symbol of it."

"As a result of that debate, I think there going to be at least big changes in the bill," Alexander added.

Healthcare is expected to be a central issue in this fall's campaign, and many Republicans have pledged to run on a pledge of repealing in whole the healthcare bill to have passed through Congress, which was signed into law by the president. 

But already, some Republicans have tempered their rhetoric on repeal, including Sens. Richard BurrRichard Mauze BurrTrump moves to boost Ted Budd in North Carolina Senate race Texas Democrat Rep. Eddie Bernice Johnson announces retirement at end of term On The Money — IRS chief calls for reinforcements MORE (R-N.C.) and Bob CorkerRobert (Bob) Phillips CorkerCheney set to be face of anti-Trump GOP How leaving Afghanistan cancels our post-9/11 use of force The unflappable Liz Cheney: Why Trump Republicans have struggled to crush her  MORE (R-Tenn.), as well as Rep. Mark KirkMark Steven KirkDuckworth announces reelection bid Brave new world: Why we need a Senate Human Rights Commission  Senate majority battle snags Biden Cabinet hopefuls MORE, a Republican candidate for Senate in Illinois.

Those more measured pledges reflect the difficulty facing Republicans in their plans, even if they were to pick up the number of seats predicted in the most generous estimates of this fall's elections. Democrats would still be able to throw up procedural roadblocks in Congress, and Obama could veto any legislation to repeal his signature domestic policy.

At least one Republican, Sen. John McCainJohn Sidney McCainDole to lie in state in Capitol Rotunda Bob Dole: A great leader of the 'Greatest Generation' The bully who pulls the levers of Trump's mind never learns MORE (Ariz.), did though suggest that the GOP is examining its options to sidestep a presidential veto in order to repeal healthcare law.