Rep. Eric CantorEric CantorSpecial interests hide behind vets on Independence Day What to watch for in Comey’s testimony Trump nominates two new DOD officials MORE (R-Va.) will run for House Minority Whip in the next Congress, a source close to the lawmaker told The Hill Wednesday.

Cantor, Republicans' Chief Deputy Whip in the House, will challenge Rep. Roy BluntRoy BluntGOP senator: Trump transgender ban ‘deserves more than a Twitter conversation’ Overnight Healthcare: Trump plays hardball on ObamaCare | Senators revive negotiations | CBO says repeal without replace would cost 32M insurance White House working with moderates on new Medicaid proposal MORE (R-Mo.) for the position.

The shake-up marks the beginning of a reshuffling of House Republican leadership after last night's losses to Democrats in congressional districts throughout the country.

Rep. Adam Putnam (R-Fla.) announced his retirement as head of the House Republican Conference. Rep. Jeb Hensarling (R-Tex.), Chairman of the conservative Republican Study Committee, is expected to seek Putnam's position, the third-ranking position in the GOP caucus.

House Minority Leader John BoehnerJohn BoehnerBoehner on Trump tweets: He gets 'into a pissing match with a skunk' every day Boehner predicts GOP will 'never' repeal, replace ObamaCare Sudan sanctions spur intense lobbying MORE (R-Ohio) has indicated he will again look to head up House Republicans' efforts in next year's Congress.

-Michael O'Brien