Rep. Eric CantorEric CantorBrat: New ObamaCare repeal bill has 'significant' changes Overnight Energy: Flint lawmaker pushes EPA for new lead rule House staffer, Monsanto vet named to top Interior posts MORE (R-Va.) will run for House Minority Whip in the next Congress, a source close to the lawmaker told The Hill Wednesday.

Cantor, Republicans' Chief Deputy Whip in the House, will challenge Rep. Roy BluntRoy BluntThis week: Congress returns to government shutdown fight AACR’s march on Washington Five hurdles to avoiding a government shutdown MORE (R-Mo.) for the position.

The shake-up marks the beginning of a reshuffling of House Republican leadership after last night's losses to Democrats in congressional districts throughout the country.

Rep. Adam Putnam (R-Fla.) announced his retirement as head of the House Republican Conference. Rep. Jeb Hensarling (R-Tex.), Chairman of the conservative Republican Study Committee, is expected to seek Putnam's position, the third-ranking position in the GOP caucus.

House Minority Leader John BoehnerJohn BoehnerLobbyists bounce back under Trump Business groups silent on Trump's Ex-Im nominee Chaffetz won't run for reelection MORE (R-Ohio) has indicated he will again look to head up House Republicans' efforts in next year's Congress.

-Michael O'Brien