Prior to the vote on passage, which is set for after 4 p.m., the upper chamber will engage in five-hours of debate and votes on three amendments that pertain to the legislation. 

The most controversial amendment of the three is sponsored by Sen. Tom CoburnThomas (Tom) Allen CoburnBiden and AOC's reckless spending plans are a threat to the planet NSF funding choice: Move forward or fall behind DHS establishes domestic terror unit within its intelligence office MORE (R-Okla.) and in effect would prohibit the federal government from using funds raised through patent fees for unrelated purposes.

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 The House already rejected similar language contained in that amendment, and earlier in the day Sen. Patrick LeahyPatrick Joseph LeahyPhotos of the Week: Renewable energy, gymnast testimonies and a Met Gala dress Senators denounce protest staged outside home of Justice Kavanaugh Al Franken on another Senate run: 'I'm keeping my options open' MORE (D-Vt.), who is the floor manager for the patent bill, said its additon would likely “kill” patent reform efforts.

The other two amendments offered by Sens. Jeff SessionsJefferson (Jeff) Beauregard SessionsOvernight Hillicon Valley — Apple issues security update against spyware vulnerability Stanford professors ask DOJ to stop looking for Chinese spies at universities in US Overnight Energy & Environment — Democrats detail clean electricity program MORE (R-Ala.) and Maria CantwellMaria Elaine CantwellDelta variant's spread hampers Labor Day air travel, industry recovery Wyden asks White House for details on jet fuel shortage amid wildfire season Air travel hits pandemic high MORE (D-Wash.), pertain to patent term extensions and a transitional program for covered business method patents, respectively.

Before adjourning the Senate at about 8 p.m. Reid also outlined the schedule for the rest of the week saying the Senate would move to a procedural vote on a joint resolution of disapproval of the president’s exercise of authority to increase the debt limit. That vote will occur after President Obama delivers his "jobs" speech to a joint session of Congress on Thursday night.

Reid said if that resolution is taken up he might hold the Senate open “for a long time” on Friday to "dispose" of it.

The Senate is set to return at 9:30 a.m. on Thursday.