The Senate voted 61-30 on Monday to begin debate on legislation that would create workplace protections for gay and transgender people in all 50 states.

The Employment Non-Discrimination Act (ENDA) received the 60 votes needed to overcome a filibuster, and will now have to move through a series of procedural hurdles before final Senate passage, which is expected later this week.

Seven Republicans joined Democrats in voting to advance the bill: Sens. Susan CollinsSusan Margaret CollinsAgainst mounting odds, Biden seeks GOP support for infrastructure plan Trump's early endorsements reveal GOP rift The Hill's Morning Report - Biden assails 'epidemic' of gun violence amid SC, Texas shootings MORE (Maine), Kelly AyotteKelly Ann AyotteOvernight Defense: NATO expanding troops in Iraq Overnight Defense: New START extended for five years | Austin orders 'stand down' to tackle extremism | Panel recommends Biden delay Afghanistan withdrawal Study group recommends Biden delay Afghanistan withdrawal MORE (N.H.), Rob PortmanRobert (Rob) Jones PortmanHillicon Valley: Biden nominates former NSA deputy director to serve as cyber czar | Apple to send witness to Senate hearing after all | Biden pressed on semiconductor production amid shortage Bipartisan lawmakers signal support for Biden cybersecurity picks GOP Ohio Senate candidate asked to leave RNC retreat MORE (Ohio), Pat Toomey (Pa.), Dean HellerDean Arthur HellerOn The Trail: Democrats plan to hammer Trump on Social Security, Medicare Lobbying World Democrats spend big to put Senate in play MORE (Nev.), Mark KirkMark Steven KirkDuckworth announces reelection bid Brave new world: Why we need a Senate Human Rights Commission  Senate majority battle snags Biden Cabinet hopefuls MORE (Ill.) and Orrin HatchOrrin Grant HatchPress: Forget bipartisanship — it's dead! Privatization of foster care has been a disaster for children Remembering Ted Kennedy highlights decline of the Senate MORE (Utah).

Another GOP supporter of ENDA, Sen. Lisa MurkowskiLisa Ann MurkowskiNixed Interior nominee appointed to different department role  Against mounting odds, Biden seeks GOP support for infrastructure plan GOP Senate campaign arm awards Trump as he rails against McConnell MORE (Alaska), was not present for the vote.

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"The right to work is fundamental," Collins said on the Senate floor. "How can we in good conscious deny that right to any LGBT individual? … It’s simply the right thing to do to pass this bill."

The bill, S. 815, would ban workplace discrimination based on sexual orientation and gender identity. Democrats and gay rights groups say ENDA is needed because not every state has approved such protections.

The Equal Employment Opportunity Commission would enforce the new workplace rules.

The White House said President Obama “welcomes the Senate’s bipartisan first step” toward passage of the bill.

“[Obama] thanks the lawmakers from both sides of the aisle who have stood up for America’s core values of fairness and equality,” said White House press secretary Jay Carney in a statement.

Sen. Tammy BaldwinTammy Suzanne BaldwinMary Trump joining group that supports LGBTQ+ female candidates Johnson says leaving office after 2022 'probably my preference now' Democrats push Biden to include recurring payments in recovery package MORE (D-Wis.), the first openly gay U.S. senator, said the vote was about “freedom, fairness and opportunity” and said Republicans who support the bill would be remembered for their “courage.”

ENDA, which was first proposed in 1994, passed the House in 2007 but has never passed the Senate.

Senate Majority Leader Harry ReidHarry Mason ReidWhite House races clock to beat GOP attacks Harry Reid reacts to Boehner book excerpt: 'We didn't mince words' The Memo: Biden seeks a secret weapon — GOP voters MORE (D-Nev.) said a federal law is needed “to ensure all Americans, no matter where they are, will not be afraid to go to work.”

But even if the bill passes the Senate, as expected, it appears to be going nowhere in the Republican House.

Speaker John BoehnerJohn Andrew BoehnerA leadership menagerie of metaphorical scapegoats Boehner says 'unemployed' Trump 'has nothing else to do' but 'cause trouble' Boehner: 'There's a lot of leaders in the Republican Party' MORE (R-Ohio) on Monday said he is opposed to ENDA because it could open businesses up to lawsuits.

“The Speaker believes this legislation will increase frivolous litigation and cost American jobs, especially small business jobs,” said BoehnerJohn Andrew BoehnerA leadership menagerie of metaphorical scapegoats Boehner says 'unemployed' Trump 'has nothing else to do' but 'cause trouble' Boehner: 'There's a lot of leaders in the Republican Party' MORE spokesman Michael Steel.

Boehner's office also said the Speaker believes current law already prohibits employers from firing their workers because of their sexual orientation.

Conservative groups, such as Heritage Action, have urged members of Congress to block ENDA, warning it would undercut First Amendment freedoms.

“The legislation would severely undermine civil liberties, increase government interference in the labor market, and trample on religious liberty,” Heritage Action said in a statement.

Democrats have included language in the bill that would exempt military and religious organizations from complying with the nondiscrimination measure.

GOP senators on the Senate Health, Education, Labor and Pensions (HELP) Committee said they are worried about how the bill would be applied to schools. They produced a report that warned ENDA’s language is "too vague for employers to understand."

"S. 815 would force employers to ignore and silence the concerns of fellow employees, customers, and other users of their facilities," the GOP senators wrote. "The repercussions of disregarding such concerns could be devastating to an employer."

Obama has backed the legislation, saying it is “offensive” and “wrong” that some states allow individuals to be fired based on their sexual orientation.

HELP Committee Chairman Tom HarkinThomas (Tom) Richard HarkinWe need a voting rights workaround Romney's TRUST Act is a Trojan Horse to cut seniors' benefits Two more parting shots from Trump aimed squarely at disabled workers MORE (D-Iowa) noted that 17 states already have laws against employment discrimination for the LGBT community and said those rules should apply nationwide.

“A vast majority believe everyone has the right to earn a living wage without discrimination,” Harkin said. “This is another step in the direction of opening America up and making our society more inclusive rather than exclusive.”

Harkin said he hoped senators would file only amendments that are germane to the bill.

Senate Minority Leader Mitch McConnellAddison (Mitch) Mitchell McConnellTrump: McConnell 'helpless' to stop Biden from packing court Senate GOP opens door to earmarks McConnell sidesteps Trump calling him 'dumb son of a b----' MORE (R-Ky.) and Sen. Rand PaulRandal (Rand) Howard PaulCharles Booker launches exploratory committee to consider challenge to Rand Paul Rand Paul calls Fauci a 'petty tyrant' Biden picks vocal Trump critics to lead immigration agencies MORE (R-Ky.) have introduced a national right-to-work amendment to ENDA.

Their amendment, which likely will be blocked by Senate Democrats, aims to prohibit labor unions from forcing some employees to pay union dues. Nearly half of the states have right-to-work laws on the books.

— This story was updated at 6:50 p.m.