The Senate rejected House Budget Committee Chairman Paul RyanPaul Davis RyanEmbattled Juul seeks allies in Washington Ex-Parkland students criticize Kellyanne Conway Latina leaders: 'It's a women's world more than anything' MORE’s (R-Wis.) budget Thursday night.

Senate Budget Committee Chairwoman Patty MurrayPatricia (Patty) Lynn MurrayOvernight Health Care: Planned Parenthood to leave federal family planning program absent court action | Democrats demand Trump withdraw rule on transgender health | Cummings, Sanders investigate three drug companies for 'obstructing' probe Democrats demand Trump officials withdraw rule on transgender health The Hill's Morning Report - Progressives, centrists clash in lively Democratic debate MORE (D-Wash.) forced Senate Republicans to vote on Paul’s plan through an amendment she offered, which failed on a 40-59 vote.

GOP Sens. Susan CollinsSusan Margaret CollinsCook Political Report moves Susan Collins Senate race to 'toss up' The Hill's Morning Report — Trump and the new Israel-'squad' controversy Trump crosses new line with Omar, Tlaib, Israel move MORE (Maine), Dean HellerDean Arthur HellerThis week: Barr back in hot seat over Mueller report Trump suggests Heller lost reelection bid because he was 'hostile' during 2016 presidential campaign Trump picks ex-oil lobbyist David Bernhardt for Interior secretary MORE (Nev.), Mike LeeMichael (Mike) Shumway LeeMcConnell, allies lean into Twitter, media 'war' Conservatives buck Trump over worries of 'socialist' drug pricing Criminal justice reform should extend to student financial aid MORE (Utah), Rand PaulRandal (Rand) Howard PaulGraham promises ObamaCare repeal if Trump, Republicans win in 2020 Conservatives buck Trump over worries of 'socialist' drug pricing Rand Paul to 'limit' August activities due to health MORE (Ky.) and Ted CruzRafael (Ted) Edward Cruz3 real problems Republicans need to address to win in 2020 The Hill's Morning Report - Trump on defense over economic jitters Democrats keen to take on Cornyn despite formidable challenges MORE (Texas) voted with Democrats against Ryan's plan. Sen. Marco RubioMarco Antonio RubioTrump moves forward with F-16 sale to Taiwan opposed by China The Hill's Morning Report — Trump and the new Israel-'squad' controversy Trump crosses new line with Omar, Tlaib, Israel move MORE (R-Fla.), a prospective 2016 GOP presidential nominee, voted for Ryan's budget.

"Enough is enough. Republicans received a vote on their extreme proposal; now that it has failed once more, it's time for Republicans to work with Democrats to enact a budget that reflects our values of fairness and opportunity for all," House Minority Leader Nancy Pelosi (D-Calif.) said after the vote.

Ahead of the vote, Sen. John ThuneJohn Randolph ThuneSchumer blasts 'red flag' gun legislation as 'ineffective cop out' Lawmakers jump-start talks on privacy bill Trump border fight throws curveball into shutdown prospects MORE (R-S.D.) urged his colleagues to support Ryan's budget.

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"The House Republican budget does something the Democrats' doesn’t do, it actually balances," Thune said. "If you look at the House Republican budget, it’s focused on growing the economy, not the government." 

Ryan’s budget passed in the House Thursday morning on a 221-207 vote. His plan would reform the tax code in order to pay for a tax rate deduction, among other things. Ryan would reduce the top tax rate to 25 percent — a reduction of more than 10 percentage points. 

Democrats have said that Ryan would have to raise taxes on the middle class by ending tax deductions that benefit families in order to pay for tax cuts to the wealthiest.

"Our budget uses new revenue from the wealthiest Americans and biggest corporations for deficit reduction, and for investments that support our economy and strengthen our middle class," Murray said. “But the House Republican budget would do the opposite."

Murray’s budget includes $100 billion in stimulus funding that she says would help boost economic growth and workforce training. Her plan has come under heavy fire from Republicans who say it over-estimates the extent to which it would reduce the deficit, and it raises nearly $1 trillion in new taxes. Democrats say their budget cuts the deficit by $1.85 trillion over 10 years through an equal amount of spending cuts and new revenue, but the GOP has said that because it assumes the sequester will not happen, the amount of deficit reduction is closer to $700 billion.

Murray said Americans prefer her "balanced" approach over Ryan's "unbalanced" plan because her plan includes revenue and spending cuts. She added that the public rejected Ryan's budget ideas in the November election.

"Americans want to see a budget that puts the middle class first, and asks the wealthiest Americans and biggest corporations to do their fair share towards deficit reduction," Murray said. “Unfortunately, rather than meeting the clear demands of the vast majority of the American people, House Republicans put forward a budget last week that doubles down on that rejected ideology."

Ryan balances the budget over 10 years with $5.7 trillion in projected spending cuts. Democrats have criticized his plan for "gutting" programs that benefit the middle class and turn Medicare into a voucher system.

Sen. Debbie StabenowDeborah (Debbie) Ann StabenowUSDA eases relocation timeline as researchers flee agency USDA office move may have broken law, watchdog says Senate Democrats see Warren, Sanders proposals as unfeasible MORE (D-Mich.) offered an amendment that would prevent Medicare from becoming a voucher program. Her amendment received a 96-3 vote.

Cruz, Lee and Paul voted against Stabenow's amendment.

“I am proud that the Senate Budget preserves and protects Medicare for seniors today and in the future," Murray said. “Medicare is vital to the health and well being of more than 50 million seniors and Americans with disabilities."

The Senate reached a deal to hold five amendment votes Thursday night and will vote on six more amendments Friday morning at 11 a.m., while the 50 hours of required debate continues. Debate time could be yielded back in order to start the "vote-a-rama" on an unlimited number of germane amendments before 7 p.m. Friday.

—This article was updated at 9:38 p.m. to include Rep. Nancy Pelosi's (D-Calif.) statement.