“ObamaCare was passed with many promises, and in reality, it has not delivered,” Cruz said ahead of the vote. “ObamaCare is hurting young people, it’s hurting seniors, it’s hurting Hispanics, it’s hurting African-Americans, it’s hurting the economy and it should be repealed."

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The Senate is considering Budget Committee Chairwoman Patty MurrayPatricia (Patty) Lynn MurraySenate rejects government-wide ban on abortion funding Overnight Health Care: Dem chair plans hearing on Medicare for all | Senate GOP talks drug prices with Trump health chief | PhRMA CEO hopeful Trump reverses course on controversial pricing proposal Bold, bipartisan action on child care will win plenty of friends MORE’s (D-Wash.) budget, which would reduce the deficit by $1.85 trillion over 10 years through an equal amount of spending reductions and revenue increases.

House Budget Committee Chairman Paul RyanPaul Davis RyanGOP can't excommunicate King and ignore Trump playing to white supremacy and racism House vote fails to quell storm surrounding Steve King House passes resolution condemning white nationalism MORE’s (R-Wis.) plan balances the budget in 10 years through $5.7 trillion in projected spending reductions. Democrats criticize his plan because he repeals the Affordable Care Act and would turn Medicare into a voucher system.

“The Senate budget commits to ensuring the full implementation of the Affordable Care Act, so that we can continue building a stronger and more sustainable healthcare system for all Americans,” Murray said. “Unfortunately, the House Republican budget would do the opposite.”

Republicans say Obama’s signature healthcare law hurts the economy and raises taxes on the public and businesses.

The Senate also rejected an amendment from Sen. Mike CrapoMichael (Mike) Dean CrapoSenate advances measure bucking Trump on Russia sanctions Deutsche Bank targeted by Dems over Trump ties Senators offer measure naming Saudi crown prince 'responsible' for Khashoggi slaying MORE (R-Idaho), which would have repealed the tax increases on individuals from the Affordable Care Act. Crapo’s amendment was rejected on a 45-54 vote Friday.

“ObamaCare itself includes some 20 tax increases over $1 trillion,” Cruz said. “Many of those tax increases fall of the middle class.”

But some healthcare related amendments succeeded. On Friday, the Senate accepted Sen. Jeanne ShaheenCynthia (Jeanne) Jeanne ShaheenGOP reasserts NATO support after report on Trump’s wavering Some Senate Dems see Ocasio-Cortez as weak spokeswoman for party The Hill's Morning Report — Trump eyes wall money options as shutdown hits 21 days MORE’s (D-N.H.) amendment to protect women’s healthcare coverage and employer-provided contraceptive coverage authorized under the Affordable Care Act. That amendment passed on a 56-43 vote.

Some Republicans argue that employers shouldn’t have to fund contraception if they disagree with it for moral and religious reasons.

"We must also protect the deeply religious beliefs in this country," Sen. Mike JohannsMichael (Mike) Owen JohannsMeet the Democratic sleeper candidate gunning for Senate in Nebraska Farmers, tax incentives can ease the pain of a smaller farm bill Lobbying World MORE (R-Neb.) said. "This law tramples on the rights of individuals." 

Shaheen said that her amendment makes sure a woman’s family planning decisions “are not dictated by government or her employer.”

“The United States has one of the highest rate of unintended pregnancies in the developed world,” Shaheen said. “Preventing unintended pregnancies just makes sense.”

GOP Sens. Susan CollinsSusan Margaret CollinsOvernight Defense: Trump unveils new missile defense plan | Dems express alarm | Shutdown hits Day 27 | Trump cancels Pelosi foreign trip | Senators offer bill to prevent NATO withdrawal McConnell blocks bill to reopen most of government Bipartisan senators reintroduce bill to prevent Trump from withdrawing from NATO MORE (Maine), Mark KirkMark Steven KirkDems vow swift action on gun reform next year This week: Trump heads to Capitol Hill Trump attending Senate GOP lunch Tuesday MORE (Ill.) and Lisa MurkowskiLisa Ann MurkowskiKaine to force Senate to hold rare Saturday session amid shutdown Senate rejects government-wide ban on abortion funding Senators look for possible way to end shutdown MORE (Alaska) voted with most Democrats — Sen. Joe ManchinJoseph (Joe) ManchinSenate rejects government-wide ban on abortion funding Centrist efforts to convince Trump to end shutdown falter Bipartisan group of senators will urge Trump to reopen government for 3 weeks MORE (D-W.V.a) was the only Democrat to vote against Shaheen's amendment.

On Thursday night, senators voted 79-20 to repeal a 2.3 percent medical device tax, which was enacted as part of Obama’s healthcare law. Sen. Orrin HatchOrrin Grant HatchPhRMA CEO 'hopeful' Trump officials will back down on drug pricing move Live coverage: Trump AG pick grilled on Mueller probe at confirmation hearing Trump praises RNC chairwoman after she criticizes her uncle Mitt Romney MORE (R-Utah) introduced that amendment.

The Senate will continue debate on the budget until about 3 p.m. Friday. Then it will have a "vote-a-rama" on an unlimited number of germane amendments until final passage.

Murray’s budget includes $100 billion in stimulus funding that Democrats say will help economic growth and workforce training. 

Republicans have said the budget overestimates the extent to which it would reduce the deficit, and raises $1 trillion in new taxes. Democrats say their budget cuts the deficit by $1.85 trillion over 10 years through an equal amount of spending cuts and new revenue, but the GOP has said that because it assumes the sequester will not happen, the amount of deficit reduction is closer to $700 billion.

This article was updated at 12:30 p.m. to include the votes on Shaheen and Crapo's amendments.