Rubio was responding to a question from a constituent on why the immigration bill can’t be dealt with in a piecemeal approach rather than a large comprehensive bill. Rubio said that because immigration reform is “complex,” a large bill is the best approach. He said that border enforcement and worker visas have to be dealt with at the same time because the issues are "interwoven."

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“The problem with immigration though is that it is complex because it is all interwoven,” Rubio said. “It’s all related to each other. It’s literally impossible to do one part without doing the other.”

The Senate is expected to begin floor debate on the Border Security, Economic Opportunity, and Immigration Modernization Act later this month.

The bipartisan group of eight senators, known as the Gang of Eight, introduced S. 744, which would create a pathway to citizenship for illegal immigrants already in the country, toughen border security, create a guest worker program and boost high-skilled immigration.

Sens. Rubio, John McCainJohn Sidney McCainCongress brings back corrupt, costly, and inequitably earmarks Trump knocks CNN for 'completely false' report Gaetz was denied meeting The Hill's Morning Report - Presented by Tax March - Biden, lawmakers start down a road with infrastructure MORE (R-Ariz.), Lindsey GrahamLindsey Olin GrahamWall Street spent .9B on campaigns, lobbying in 2020 election: study Biden aide: Ability to collect daily intel in Afghanistan 'will diminish' Leaving Afghanistan: Is it victory or defeat? MORE (R-S.C.), Jeff FlakeJeffrey (Jeff) Lane FlakeFive reasons why US faces chronic crisis at border Senate GOP faces retirement brain drain Former GOP lawmaker: Republican Party 'engulfed in lies and fear' MORE (R- Ariz.), Charles SchumerChuck SchumerSchumer lays groundwork for future filibuster reform Holder, Yates lead letter backing Biden pick for Civil Rights Division at DOJ Capitol Police officer killed in car attack lies in honor in Capitol Rotunda MORE (D-N.Y.), Dick DurbinDick DurbinLawmakers demand justice for Adam Toledo: 'His hands were up. He was unarmed' Schumer warns Democrats can't let GOP block expansive agenda Holder, Yates lead letter backing Biden pick for Civil Rights Division at DOJ MORE (D-Ill.), Robert MenendezRobert (Bob) MenendezBottom line The Memo: Biden's five biggest foreign policy challenges Democrats gear up for major push to lower drug prices MORE (D-N.J.) and Michael BennetMichael Farrand BennetDemocrats get good news from IRS Senators press for answers in Space Command move decision Biden announces first slate of diverse judicial nominees MORE (D-Co.) comprise the Gang of Eight.

The Senate Judiciary Committee passed the bill out of committee last month on a bipartisan vote. Rubio said more work is needed to improve the legislation so it can pass in the House.

“There will have to be improvements,” Rubio said. “Because the good thing is the American people, the vast majority of them throughout the political spectrum, have clearly said that they are prepared to responsibly deal with those that are here illegally, but they are only willing to do so if we can take measures that ensure that this problem will never happen again in the future. And so, if we can make sure we put in place enforcement mechanisms and a guest worker program that ensures this will never happen again in the future, we’re going to have responsible immigration reform. And if we don’t have that, then we won’t have immigration reform.”

Some Republicans have complained that the legislation is being rushed through, and that it would provide amnesty for illegal residents before strengthening border enforcement enough.

House Republicans have said they will produce their own immigration reform bill, but that it would likely be passed in pieces rather than one large comprehensive bill.