The Senate on Thursday voted 54-46 to confirm Tom Perez as secretary of Labor.

It was a party-line vote, with no Republicans supporting President Obama's nominee.

Several GOP senators have charged that Perez had engaged in “ethically questionable” actions while heading the Civil Rights division of the Department of Justice.

Republicans agreed to hold an up-or-down vote on the nomination as part of a deal to avoid the "nuclear option" to end filibusters, but they made clear their strong disapproval of Perez on Thursday.

Senate Minority Leader Mitch McConnellAddison (Mitch) Mitchell McConnellOn The Money: Senate banking panel showcases 2020 Dems | Koch groups urge Congress not to renew tax breaks | Dow down nearly 400 | Cuomo defends Amazon HQ2 deal GOP senator accuses fellow Republican of spreading ‘fake news’ about criminal justice reform bill The Hill's 12:30 Report - New White House threat to Acosta's press pass | Trump defends criticism of McRaven | Hamilton biographer to headline WHCA dinner MORE (R-Ky.) accused the new Labor secretary of making "misleading" statements to Congress and an inspector general during his service in the administration.

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“Tom Perez is more than just some left-wing ideologue, he’s a left-wing ideologue who appears perfectly willing to bend the rules to achieve his ends,” McConnell said. “This is reflective not of some passionate left-winger who views himself as patiently advancing policies within the bounds of a democratic system but as a crusading ideologue whose convictions lead him to believe that the law simply doesn’t apply to him.”

Sen. Marco RubioMarco Antonio RubioTrump stokes new unlikely feud Despite recount drama, high level of voter confidence in U.S. electoral system Former Navy SEAL who killed bin Laden defends mission after Trump criticism MORE (R-Fla.) urged his Republican colleagues to vote no because he said Perez had failed to answer lawmakers’ questions during congressional hearings.

“How can we possibly — I don’t care what deal was cut — how can we move forward on someone who hasn’t provided information asked for by a congressional committee?”

Democrats defended Perez and hailed the end of the months-long Senate battle over his confirmation.

“Filling the position of Labor secretary couldn’t be more important,” Sen. Patty MurrayPatricia (Patty) Lynn MurrayOvernight Health Care — Presented by The Partnership for Safe Medicines — FDA restricts sales of flavored e-cigs | Proposes ban on menthol in tobacco | Left wants vote on single-payer bill in new Congress | More than 12k lost Medicaid in Arkansas Schumer reelected as Senate Democratic Leader Senate GOP readies for leadership reshuffle MORE (D-Wash.) said ahead of the vote. “Our country and our economy are stronger when the Department of Labor has a talented and qualified leader at the reins. … The president has nominated someone who will bring passion, integrity and a lifetime of experience to this important position.”

Senate Health, Education, Labor and Pensions Committee Chairman Tom HarkinThomas (Tom) Richard HarkinOn Nicaragua, the silence of the left is deafening Dem Senator open to bid from the left in 2020 Senate GOP rejects Trump’s call to go big on gun legislation MORE (D-Iowa) said Perez has the "strongest reputation of professional integrity" and has acted "ethically."