The Senate voted 53-42 Wednesday to confirm the nomination of B. Todd Jones to lead the Bureau of Alcohol, Tobacco, Firearms and Explosives (ATF).

The vote came after nearly five hours of delay. Democratic Sen. Heidi HeitkampMary (Heidi) Kathryn HeitkampRed dresses displayed around American Indian museum to memorialize missing, murdered native women Lobbying World Lobbying World MORE had to fly back from her home state of North Dakota at the last minute after Democrats came up one vote short of ending debate on the nomination.

Six Republicans voted with Democrats to end debate in a 60-40 vote. Sen. Lisa MurkowskiLisa Ann MurkowskiRed dresses displayed around American Indian museum to memorialize missing, murdered native women Juan Williams: Don't rule out impeaching Trump The 25 Republicans who defied Trump on emergency declaration MORE (R-Alaska) switched her vote to advance Jones’s nomination after her colleagues pressured her on the Senate floor. She joined GOP Sens. Susan CollinsSusan Margaret CollinsSenate GOP poised to go 'nuclear' on Trump picks Overnight Health Care: CDC pushes for expanding HIV testing, treatment | Dem group launches ads attacking Trump on Medicare, Medicaid cuts | Hospitals, insurers spar over surprise bills | O'Rourke under pressure from left on Medicare for all Dem group launches ads attacking Trump's 'hypocrisy on Medicare and Medicaid cuts' MORE (Maine), Kelly AyotteKelly Ann AyotteSchultz recruiting GOP insiders ahead of possible 2020 bid Bottom Line US, allies must stand in united opposition to Iran’s bad behavior MORE (N.H.), Lindsey GrahamLindsey Olin GrahamThe Hill's Morning Report - Trump's intraparty feuds divide Republicans Trump's attacks on McCain exacerbate tensions with Senate GOP Republicans defend McCain amid Trump attacks MORE (S.C.), John McCainJohn Sidney McCainEx-senator challenges Trump to get X-rays proving he had bone spurs during Vietnam draft McSally spoke with Trump, said McCain deserved respect Trump rolls dice on uncertain economy MORE (Ariz.) and Mark KirkMark Steven KirkThe global reality behind 'local' problems Dems vow swift action on gun reform next year This week: Trump heads to Capitol Hill MORE (Ill.). 

Ranking member of the Senate Judiciary Committee Chuck GrassleyCharles (Chuck) Ernest GrassleyOvernight Health Care: Senators seek CBO input on preventing surprise medical bills | Oversight panel seeks OxyContin documents | Pharmacy middlemen to testify on prices | Watchdog warns air ambulances can put patients at 'financial risk' Drug prices are a matter of life and death Senate panel to hear from pharmacy middlemen on drug prices MORE (R-Iowa) said he wouldn’t support Jones’s nomination because he is accused of “retaliating against a whistle-blower.”

“The Senate should not be voting on a nomination when there is an open investigation,” Grassley said ahead of the vote. “To be honest, we don’t know the full story, but there is an open investigation of serious accusations on retaliation against whistle-blower activity. ... These are serious charges.”

Grassley said promoting Jones would not help restore public confidence in the bureau after the “botched” “Fast and Furious” gun-walking operation.

The ATF hasn’t had a leader for seven years. Democrats have complained that Republicans have opposed directors for the bureaubecause of the National Rifle Association’s powerful lobby. 

Sen. Amy KlobucharAmy Jean KlobucharHarris's stepkids call her 'Momala' Sanders joins striking workers at UCLA in first 2020 California visit Lawmakers urge tech to root out extremism after New Zealand MORE (D-Minn.), who serves on the Senate Judiciary Committee, said the agency “deserves” a leader.

“There are 24,000 ATF agents and they have gone without a leader for seven years, since it became an appointment position,” Klobuchar said. “It is simply time to change that.”

Jones has served as the Minnesota U.S. attorney and acting director of ATF. 

Earlier this month, the Senate Judiciary Committee cleared his nomination on a party-line, 10-8 vote.

— Updated at 8:42 p.m.