Senators on Wednesday rejected a key proposal that would repeal much of ObamaCare, despite intense pressure from conservatives.

Senators voted 55-45 against an amendment from Sen. Rand PaulRandal (Rand) Howard PaulThe 25 Republicans who defied Trump on emergency declaration Overnight Defense: Senate rejects border emergency in rebuke to Trump | Acting Pentagon chief grilled on wall funding | Warren confronts chief over war fund budget 12 Republican senators defy Trump on emergency declaration  MORE (R-Ky.) that would repeal the Affordable Care Act and give lawmakers two years to come up with a replacement.

GOP Sens. Lamar AlexanderAndrew (Lamar) Lamar AlexanderThe 25 Republicans who defied Trump on emergency declaration Trump issues first veto, warning of 'reckless' resolution Overnight Defense: Senate rejects border emergency in rebuke to Trump | Acting Pentagon chief grilled on wall funding | Warren confronts chief over war fund budget MORE (Tenn.), Shelley Moore CapitoShelley Wellons Moore CapitoPence, GOP senators discuss offer to kill Trump emergency disapproval resolution Bipartisan think tank to honor lawmakers who offer 'a positive tenor' Trump tries to win votes in Senate fight MORE (W.Va.), Susan CollinsSusan Margaret CollinsRepublicans up for reelection fear daylight with Trump The 25 Republicans who defied Trump on emergency declaration The Hill's Morning Report — Trump readies first veto after latest clash with Senate GOP MORE (Maine), Dean HellerDean Arthur HellerTrump suggests Heller lost reelection bid because he was 'hostile' during 2016 presidential campaign Trump picks ex-oil lobbyist David Bernhardt for Interior secretary Oregon Dem top recipient of 2018 marijuana industry money, study finds MORE (Nev.), John McCainJohn Sidney McCainCNN anchor hits Trump: He didn't go to Vietnam 'until he was in his 70s' with 'Secret Service protection' Trump reignites criticism of McCain months after senator's death Graham defends McCain amid Trump attacks: 'Nothing about his service will ever be changed' MORE (Ariz.), Lisa MurkowskiLisa Ann MurkowskiThe 25 Republicans who defied Trump on emergency declaration Overnight Defense: Senate rejects border emergency in rebuke to Trump | Acting Pentagon chief grilled on wall funding | Warren confronts chief over war fund budget 12 Republican senators defy Trump on emergency declaration  MORE (Alaska) and Rob PortmanRobert (Rob) Jones PortmanThe 25 Republicans who defied Trump on emergency declaration Overnight Defense: Senate rejects border emergency in rebuke to Trump | Acting Pentagon chief grilled on wall funding | Warren confronts chief over war fund budget 12 Republican senators defy Trump on emergency declaration  MORE (Ohio) joined all Democrats and independents in voting no. 

A vote on the amendment, which was widely expected to fail, was originally scheduled for late Wednesday morning but was delayed as senators tried to get clarity on a provision tied to abortion. 

It was the second healthcare plan rejected after the Senate voted down a separate repeal-and-replace amendment on Tuesday night.

Three GOP senators had already announced they wouldn’t support repeal-only. Alexander, the chairman of the Senate’s health committee, predicted he didn’t “think there are 40 votes to repeal” without a replacement.

But conservatives ramped up pressure for GOP senators to support the proposal, noting Senate Republicans passed a repeal bill in 2015 when they knew then-President Obama would veto it.

“Republicans promised to repeal ObamaCare, and as we move forward in this process, I urge them to join me in supporting a clean repeal of as much of this disastrous law as possible,” Paul said ahead of the vote.

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FreedomWorks, a conservative outside group, blasted out a “key vote” notice hours ahead of Wednesday’s vote, arguing President Trump would sign a repeal-only bill.

“For more than seven years, Republicans successfully campaigned on ObamaCare repeal. ... Grassroots conservative activists are not going to accept excuses if Republicans fail to pass a bill that they have passed once before,” the group said in a notice to members.

Michael Needham, CEO of Heritage Action for America, added separately on Wednesday morning that "around 11:30, the Senate will vote on the 2015 repeal bill. It would be a first step towards repeal and all Senators should support it."

Repealing portions of ObamaCare without enacting a replacement could leave 18 million people without health insurance the following year, according to a report released by Congressional Budget Office (CBO) in January.

After the elimination of ObamaCare's Medicaid expansion and insurance subsidies, 27 million people would lose insurance, rising to 32 million by 2026, the CBO found.

The proposal comes as senators are searching to find a path forward on how to fulfill their years-long campaign pledge to repeal and replace ObamaCare.

Senate Majority Leader Mitch McConnellAddison (Mitch) Mitchell McConnellRepublicans up for reelection fear daylight with Trump Overnight Energy: Students around globe demand climate action | EPA bans consumer sales of deadly chemical in paint strippers | Green New Deal set for Senate vote The Hill's Morning Report — Trump readies first veto after latest clash with Senate GOP MORE (R-Ky.) scored a victory on Tuesday when he wrangled 50 GOP senators to agree to start debate on the House-passed healthcare bill, being used as a vehicle for any action, and let Vice President Pence break the 50-50 tie.

But during the first amendment vote Tuesday evening, nine GOP senators joined with Democrats and independents to vote against a key repeal-and-replace proposal, known as the Better Care Reconciliation Act (BCRA). The setback doesn’t prevent GOP leadership from offering another version of BCRA during what is expected to be a days-long floor debate with hundreds of amendments. 

McConnell said that while the proposal failed, it “represented a number of important healthcare reform ideas developed by our members.”

He added on Wednesday that the effort to get either an ObamaCare repeal, or an ObamaCare repeal and replace bill, through the Senate “certainly won’t be easy.”  

“We’ll consider many different proposals throughout this process from senators on both sides of the aisle. Ultimately, we want to get legislation to finally end the failed ObamaCare status quo through Congress and to the president’s desk for his signature,” he said Wednesday morning.

Republicans have a 52-seat majority and will need the support of at least 50 senators to pass a proposal.

GOP leadership could ultimately try to pass a “skinny repeal,” which would include a repeal of the individual and employer mandates and the medical device tax, if broader proposals aren’t able to garner enough support.

The move could buy Republicans time to work out a deal as they try to merge their healthcare bill with a proposal passed earlier this year by the House.

“I think the endgame is to be able to move something at the end of this process across the Senate floor that can get 50 votes and then get into conference with the House,” Sen. John ThuneJohn Randolph ThuneSenators offer bipartisan bill to fix 'retail glitch' in GOP tax law GOP's Tillis comes under pressure for taking on Trump We need a national privacy law that respects the First Amendment MORE (R-S.D.) told reporters.

Sen. John CornynJohn CornynJulian Castro hints at brother Joaquin's Senate run Joaquin Castro closing in on 2020 Senate bid: report Five questions for Beto O'Rourke MORE (R-Texas), the No. 2 Senate Republican, added on Wednesday that the GOP wants to "get to conference quick" but no decisions had been made about what the Senate could ultimately pass, or what could be included in a "skinny repeal."

Democrats, however, have blasted that path as a setup to try to ultimately pass full repeal of ObamaCare.

“Make no mistake about it, skinny repeal is equal to full repeal. It’s a Trojan horse designed to get the House and Senate into conference where the hard-right flank of the Republican caucus, the Freedom Caucus, will demand full repeal or something very close to it,” Senate Minority Leader Charles Schumer (D-N.Y.) said ahead of the vote.