The six most memorable political moments from this year's Oscars

Politics dominated the night during the 90th annual Academy Awards on Sunday, with some of Hollywood’s biggest stars tackling sexual harassment, LGBT rights, immigration reform and other hot-button issues.

Here are the six most memorable political moments during this year's Oscars ceremony.

Kimmel touts #MeToo in opening monologue

Second-time host Jimmy Kimmel didn’t shy away from skewering Hollywood for its treatment of women, kicking off the awards show with a monologue filled with one-liners taking aim at the entertainment industry.

“Here’s how clueless Hollywood is about women: We made a movie called ‘What Women Want’ and it starred Mel Gibson. That’s all you need to know,” said the late-night host.

Kimmel went on to hail the "Me Too" movement, telling the crowd in Los Angeles: “The world is watching us. We need to set an example.”

Nyong’o, Nanjiani share support for 'Dreamers'

Presenters Lupita Nyong’o and Kumail Nanjiani took to the stage to make an impassioned plea for "Dreamers."

“Black Panther” star Nyong’o, who's from Kenya, and Nanjiani, who told the crowd he's from Pakistan and Iowa, shared their support for Dreamers, the term frequently used to refer to young immigrants who were brought to the U.S. illegally as children. The Trump administration announced last year it was rescinding the Deferred Action for Childhood Arrivals program that protected those immigrants, putting their fate in doubt.

“Like everyone in this room, and everyone watching at home, we are dreamers too,” Nyong’o said. "Dreams are the foundation of Hollywood and dreams are the foundation of America.”

“To all the Dreamers out there," Nanjiani added, "we stand with you."

First openly transgender presenter makes history

“A Fantastic Woman” star Daniela Vega made the Hollywood history books by becoming the first openly transgender person to present at the Academy Awards.

The Chilean actress, who introduced a song from the Oscar-nominated film “Call Me By Your Name,” exclaimed to the audience, “Thank you so much for this moment.”

“I want to invite you to open your heart and your feelings to feel the reality and to feel love,” Vega said.  “Can you feel it?"

Kobe Bryant jabs at Ingraham's ‘shut up and dribble’ remark

Kobe Bryant hit back at conservative commentator Laura Ingraham’s remarks that basketball players should “shut up and dribble" while accepting his first Oscar.

The former Los Angeles Laker joined animator Glen Keane as the pair accepted an award for Best Animated Short Film for their movie “Dear Basketball.”

"I mean, as basketball players we're really supposed to shut up and dribble, but I'm glad we do a little bit more than that," Bryant said.

The retired basketball player appeared to be hitting back at a remark made by Ingraham last month. Addressing basketball stars LeBron James and Kevin Durant after they criticized President TrumpDonald John TrumpSchiff urges GOP colleagues to share private concerns about Trump publicly US-China trade talks draw criticism for lack of women in pictures Overnight Defense: Trump to leave 200 troops in Syria | Trump, Kim plan one-on-one meeting | Pentagon asks DHS to justify moving funds for border wall MORE, Ingraham said, “Keep the political commentary to yourself, or, as someone once said, 'shut up and dribble.'"

Kimmel, Common take swipes at Trump and Pence

While many Hollywood stars have used recent awards shows to slam President Trump, explicitly anti-Trump rhetoric generally took a back seat at the Oscars.

However, two stars did make reference to the commander in chief during Sunday night's show.

Host Jimmy Kimmel — a frequent Trump critic on his ABC late-night show — included a single quip in his opening monologue targeting the president, saying, “None other than President Trump called ‘Get Out’ the best first three-quarters of a movie this year.”

Kimmel also raised eyebrows with a joke aimed at Vice President Pence’s stance on gay rights.

“We don’t make films like ‘Call Me By Your Name' for money,” Kimmel said of the Oscar-nominated film about a 17-year-old boy discovering his sexuality through a romantic relationship with an older man. “We make them to upset Mike PenceMichael (Mike) Richard PencePence going to Colombia to demand Maduro step down Grenell: Push to decriminalize homosexuality 'wildly supported' by both parties Marc Short to return to White House as Pence’s chief of staff MORE."

Hip-hop artist Common and Andra Day denounced Trump without uttering his name during a performance of their anthem, “Stand Up for Something.”

“A president that trolls with hate. He don’t control our fate because God is great,” Common said in spoken word.

“When they go low, we stay in the heights. I stand for peace, love, and women’s rights,” he said.

#TimesUp and #MeToo grab the Oscars spotlight

Anti-sexual harassment initiatives were front and center for much of the 2018 awards show, with the Oscars dedicating an entire segment to the “Time’s Up” and “Me Too” movements.

Ashley Judd, Salma Hayek and Annabella Sciorra — three of former Hollywood producer Harvey Weinstein’s accusers — joined together to introduce a taped segment paying homage to Hollywood’s “trailblazers.”

“The changes we are witnessing are being driven by the powerful sound of new voices, of different voices, of our voices, joining together in a mighty chorus that’s finally saying, ‘Time’s up,’” said Judd.