There was speculation in December of last year that Affleck would run for Senate in Massachusetts, to replace Secretary of State John KerryJohn Kerry Overnight Energy & Environment — Presented by Climate Power — Interior returns BLM HQ to Washington Biden confirms 30 percent global methane reduction goal, urges 'highest possible ambitions' 9/11 and US-China policy: The geopolitics of distraction MORE. Affleck, a Boston native, and Kerry are close. The actor campaigned for Kerry's presidential campaign in 2004.

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But Affleck opted not to run and has seen his Hollywood career flourish: His film "Argo" won the Academy Award for Best Picture earlier this year.

Affleck has remained politically active through his Eastern Congo Initiative and he's testified on Capitol Hill about ending the war in the Congo. He also held a fundraiser for Massachusetts Democrat Elizabeth WarrenElizabeth WarrenFederal Reserve officials' stock trading sparks ethics review Manchin keeps Washington guessing on what he wants Warren, Daines introduce bill honoring 13 killed in Kabul attack MORE's 2012 Senate campaign.

Garner said she would support her husband if he makes the political leap.

"I'm along for the ride," she told the magazine.