Samantha Bee is taking heat for using a profane term to describe Ivanka TrumpIvana (Ivanka) Marie TrumpTrump, Harris, Ocasio-Cortez, Charlie Kirk among Twitter's most-engaged users Ivanka must recalibrate her paid family leave plan to make it tenable Four names emerge for UN position: report MORE, whom she criticized for not challenging her father’s immigration policies.

“Ivanka Trump, who works at the White House, chose to post the second most oblivious tweet we’ve seen this week,” Bee, host of TBS's “Full Frontal," said during an opening segment on Wednesday’s show focused on separating migrant children from their parents at the Mexico–United States border.

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Displaying a Sunday tweet from President TrumpDonald John TrumpTrump nominates Jeffrey Rosen to replace Rosenstein at DOJ McCabe says ‘it’s possible’ Trump is a Russian asset McCabe: Trump ‘undermining the role of law enforcement’ MORE’s 36-year-old daughter featuring an image of her holding her son, Bee said, “You know, Ivanka, that’s a beautiful photo of you and your child, but let me just say, one mother to another: do something about your dad’s immigration practices, you feckless c---.”

Bee later apologized in a statement, calling her use of the term "inappropriate and inexcusable." 

“I would like to sincerely apologize to Ivanka Trump and to my viewers for using an expletive on my show to describe her last night," Bee said.

"I crossed a line, and I deeply regret it.”

The remark from Bee came just a day after ABC pulled the plug on Roseanne Barr’s top-rated comedy, the rebooted “Roseanne,” after the comedian posted a racist tweet targeting former Obama White House adviser Valerie Jarrett.

NBC’s Megyn Kelly called Bee’s Trump comment “disgusting,” tweeting on Thursday: 

While some defended Bee, others pounced on using the derogatory term in reference to Trump: 

—Updated at 2:31 p.m.