Filmmaker Rob Reiner slammed President TrumpDonald John TrumpTrump claims media 'smeared' students involved in encounter with Native American man Al Sharpton criticizes Trump’s ‘secret’ visit to MLK monument Gillibrand cites spirituality in 2020 fight against Trump’s ‘dark’ values MORE on Thursday, claiming he is “aiding and abetting the enemy” in the "War against Isis" and "Cyberwar against Russia."

“Donald Trump is committing Treason against The United States of America,” Reiner tweeted Thursday. “He is aiding and abetting the enemy in The War against Isis and The Cyberwar against Russia."

"He has turned the world’s oldest Democracy into a wholly owned subsidiary of Vladimir Putin. GOP, WAKE UP!” he added.  

On Friday, Reiner claimed Trump is "mentally unstable" and accused the president of taking steps to "destroy" U.S. independence.

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"Each day this mentally unstable man takes a step closer to destroying 242 yrs. of self rule. And though Democrats want to be restrained, impeachment is inevitable," he tweeted.

"Then GOP Senators will have to make a choice. Either protect Democracy or continue to enable an ignorant criminal," he added. 

Reiner's comments came one day after Trump declared victory against ISIS in Syria and announced his administration's decision to withdraw troops from the nation.

The announcement drew bipartisan criticism, prompting a group of senators from both parties to send a letter to Trump on Wednesday asking him to reconsider his decision.

“If you decide to follow through with your decision to pull our troops out of Syria, any remnants of ISIS in Syria will surely renew and embolden their efforts in the region," they wrote. 

The senators, including  Lindsey GrahamLindsey Olin GrahamGraham angers Dems by digging into Clinton, Obama controversies Barr’s first task as AG: Look at former FBI leaders’ conduct Debate builds over making Mueller report public MORE (R-S.C.), Jeanne ShaheenCynthia (Jeanne) Jeanne ShaheenGOP reasserts NATO support after report on Trump’s wavering Some Senate Dems see Ocasio-Cortez as weak spokeswoman for party The Hill's Morning Report — Trump eyes wall money options as shutdown hits 21 days MORE (D-N.H.), Joni ErnstJoni Kay ErnstTrump tells GOP senators he’s sticking to Syria and Afghanistan pullout  McConnell: Senate will not recess if government still shutdown Barr calls for 'barrier system' on border MORE (R-Iowa), Angus KingAngus Stanley KingSen. Angus King begins treatment for prostate cancer GOP senators challenge Trump on shutdown strategy Will Trump declare an emergency tonight? Only he knows for sure MORE (I-Maine), Tom CottonThomas (Tom) Bryant CottonOn The Money: Shutdown Day 26 | Pelosi calls on Trump to delay State of the Union | Cites 'security concerns' | DHS chief says they can handle security | Waters lays out agenda | Senate rejects effort to block Trump on Russia sanctions Senate rejects effort to block Trump on Russia sanctions Overnight Defense: Trump faces blowback over report he discussed leaving NATO | Pentagon extends mission on border | Senate advances measure bucking Trump on Russia sanctions MORE (R-Ark.) and Marco RubioMarco Antonio RubioRussian oligarch, allies retain key ownership in company after sanctions lifted: report Senate GOP eyes 'nuclear option' for Trump nominees next week Washington fears new threat from 'deepfake' videos MORE (R-Fla.), expressed concern that the decision would bolster Russian influence in the region. 

"As you are aware, both Iran and Russia have used the Syrian conflict as a stage to magnify their influence in the region," the senators added. "Any sign of weakness perceived by Iran or Russia will only result in their increased presence in the region and a decrease in the trust of our partners and allies."

Reiner has been a frequent critic of Trump, often taking to Twitter to lambast the president.

Reiner has called for Americans to increase their protests against the president, saying in June that he didn't think there was a "line" that could be crossed when it came to demonstrating against Trump.