Filmmaker Rob Reiner slammed President TrumpDonald John TrumpMinneapolis erupts for third night, as protests spread, Trump vows retaliation Stocks open mixed ahead of Trump briefing on China The island that can save America MORE on Thursday, claiming he is “aiding and abetting the enemy” in the "War against Isis" and "Cyberwar against Russia."

“Donald Trump is committing Treason against The United States of America,” Reiner tweeted Thursday. “He is aiding and abetting the enemy in The War against Isis and The Cyberwar against Russia."

"He has turned the world’s oldest Democracy into a wholly owned subsidiary of Vladimir Putin. GOP, WAKE UP!” he added.  

On Friday, Reiner claimed Trump is "mentally unstable" and accused the president of taking steps to "destroy" U.S. independence.

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"Each day this mentally unstable man takes a step closer to destroying 242 yrs. of self rule. And though Democrats want to be restrained, impeachment is inevitable," he tweeted.

"Then GOP Senators will have to make a choice. Either protect Democracy or continue to enable an ignorant criminal," he added. 

Reiner's comments came one day after Trump declared victory against ISIS in Syria and announced his administration's decision to withdraw troops from the nation.

The announcement drew bipartisan criticism, prompting a group of senators from both parties to send a letter to Trump on Wednesday asking him to reconsider his decision.

“If you decide to follow through with your decision to pull our troops out of Syria, any remnants of ISIS in Syria will surely renew and embolden their efforts in the region," they wrote. 

The senators, including  Lindsey GrahamLindsey Olin GrahamSenate Democrats pump brakes on new stimulus checks Comey, Rice, Clapper among GOP senator's targets for subpoenas amid Obama-era probe Schumer: GOP should 'stop sitting on their hands' on coronavirus bill MORE (R-S.C.), Jeanne ShaheenCynthia (Jeanne) Jeanne ShaheenThis week: Surveillance fight sets early test for House's proxy voting Open Skies withdrawal throws nuclear treaty into question GOP faces internal conflicts on fifth coronavirus bill MORE (D-N.H.), Joni ErnstJoni Kay ErnstThe Hill's Coronavirus Report: National Portrait Gallery's Kim Sajet says this era rewiring people's relationship with culture, art; Trump's war with Twitter heats up The Hill's 12:30 Report - Presented by Facebook - Cuomo rings the first opening bell since March House Democrats make initial ad buys in battleground states MORE (R-Iowa), Angus KingAngus KingMemorial Day weekend deals latest economic blow to travel industry Bipartisan senators introduce bill to make changes to the Paycheck Protection Program Senators weigh traveling amid coronavirus ahead of Memorial Day MORE (I-Maine), Tom CottonThomas (Tom) Bryant CottonDemocrats call on FTC to investigate allegations of TikTok child privacy violations GOP senators urge Trump not to restrict guest worker visas Chinese official accuses US of 'pushing our two countries to the brink of a new Cold War' MORE (R-Ark.) and Marco RubioMarco Antonio RubioTrump administration designates B of PPP funds for community lenders The Memo: Trump's Scarborough tweets unsettle his allies House passes bill that would sanction Chinese officials over Xinjiang camps MORE (R-Fla.), expressed concern that the decision would bolster Russian influence in the region. 

"As you are aware, both Iran and Russia have used the Syrian conflict as a stage to magnify their influence in the region," the senators added. "Any sign of weakness perceived by Iran or Russia will only result in their increased presence in the region and a decrease in the trust of our partners and allies."

Reiner has been a frequent critic of Trump, often taking to Twitter to lambast the president.

Reiner has called for Americans to increase their protests against the president, saying in June that he didn't think there was a "line" that could be crossed when it came to demonstrating against Trump.