Filmmaker Rob Reiner slammed President TrumpDonald TrumpOvernight Defense & National Security — The Pentagon's deadly mistake Overnight Energy & Environment — Presented by Climate Power — Interior returns BLM HQ to Washington France pulls ambassadors to US, Australia in protest of submarine deal MORE on Thursday, claiming he is “aiding and abetting the enemy” in the "War against Isis" and "Cyberwar against Russia."

“Donald Trump is committing Treason against The United States of America,” Reiner tweeted Thursday. “He is aiding and abetting the enemy in The War against Isis and The Cyberwar against Russia."

"He has turned the world’s oldest Democracy into a wholly owned subsidiary of Vladimir Putin. GOP, WAKE UP!” he added.  

On Friday, Reiner claimed Trump is "mentally unstable" and accused the president of taking steps to "destroy" U.S. independence.

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"Each day this mentally unstable man takes a step closer to destroying 242 yrs. of self rule. And though Democrats want to be restrained, impeachment is inevitable," he tweeted.

"Then GOP Senators will have to make a choice. Either protect Democracy or continue to enable an ignorant criminal," he added. 

Reiner's comments came one day after Trump declared victory against ISIS in Syria and announced his administration's decision to withdraw troops from the nation.

The announcement drew bipartisan criticism, prompting a group of senators from both parties to send a letter to Trump on Wednesday asking him to reconsider his decision.

“If you decide to follow through with your decision to pull our troops out of Syria, any remnants of ISIS in Syria will surely renew and embolden their efforts in the region," they wrote. 

The senators, including  Lindsey GrahamLindsey Olin GrahamThe Hill's Morning Report - Presented by National Industries for the Blind - Tight security for Capitol rally; Biden agenda slows Trump offers sympathy for those charged with Jan. 6 offenses Lindsey Graham: Police need 'to take a firm line' with Sept. 18 rally attendees MORE (R-S.C.), Jeanne ShaheenCynthia (Jeanne) Jeanne ShaheenSenate lawmakers let frustration show with Blinken We have a plan that prioritizes Afghanistan's women — we're just not using it Scott Brown's wife files to run for Congress MORE (D-N.H.), Joni ErnstJoni Kay ErnstGOP senators unveil bill designating Taliban as terrorist organization More Republicans call on Biden to designate Taliban as terrorist group Top Republican: General told senators he opposed Afghanistan withdrawal MORE (R-Iowa), Angus KingAngus KingSenate backers of new voting rights bill push for swift passage Stacey Abrams backs Senate Democrats' voting rights compromise NY Democrat tests positive for COVID-19 in latest House breakthrough case MORE (I-Maine), Tom CottonTom Bryant CottonOvernight Defense & National Security — Milley becomes lightning rod Joint Chiefs Chairman Milley becomes lightning rod on right Overnight Energy & Environment — Presented by Climate Power — Senate Democrats ding Biden energy proposal MORE (R-Ark.) and Marco RubioMarco Antonio RubioMilley says calls to China were 'perfectly within the duties' of his job Overnight Defense & National Security — Milley becomes lightning rod Joint Chiefs Chairman Milley becomes lightning rod on right MORE (R-Fla.), expressed concern that the decision would bolster Russian influence in the region. 

"As you are aware, both Iran and Russia have used the Syrian conflict as a stage to magnify their influence in the region," the senators added. "Any sign of weakness perceived by Iran or Russia will only result in their increased presence in the region and a decrease in the trust of our partners and allies."

Reiner has been a frequent critic of Trump, often taking to Twitter to lambast the president.

Reiner has called for Americans to increase their protests against the president, saying in June that he didn't think there was a "line" that could be crossed when it came to demonstrating against Trump.