Debra Messing on Monday at first defended and the later apologized for saying she hopes President TrumpDonald TrumpSchumer: Impeachment trial will be quick, doesn't need a lot of witnesses Nurse to be tapped by Biden as acting surgeon general: report Schumer calls for Biden to declare climate emergency MORE is the "most popular boyfriend" in prison.

The "Will & Grace" star — one of Hollywood's most vocal Trump critics — expressed a desire for the president to "live a long life in prison" in a tweet to her more than 677,000 followers last week.

She called Trump "a weak, scared, stupid, inept, negligent, vindictive, narcissistic, criminal" before writing she hoped he became "the most popular boyfriend to the all inmates."

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Several social media users took to Twitter to blast the 52-year-old actress as "ignorant" and "homophobic" for the remark.

The NBC sitcom Messing starred in, which ran on the network from 1998 to 2006 before being revived again in 2017 until this year, was considered groundbreaking for featuring a gay lead character.

In a Monday Twitter post, Messing responded to critics, calling herself a "LGBTQI ally."

"Trump has perpetrated violence on hundreds of millions of people," she wrote. "My hope is (and this is the first time in my life) that the tables are turned and he is the victim of perpetrators."

Hours later in a separate tweet, she struck a more contrite tone, saying she "had wished the tables turned on" Trump but would now like to "apologize for the offensive way I did it."

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It's not the first time one of Messing's anti-Trump tweets has raised eyebrows.

Last year, Trump said that NBC should fire her after she said the names of the commander in chief's donors who attended a fundraiser should be publicly identified.

—Updated at 7:50 p.m.