"Saturday Night Live" took on the nation's vaccine rollout in a sketch starring cast members playing Anthony FauciAnthony FauciVaccinated Fauci hosts people at home, but stays away from crowded indoor spaces Trump endorses Rand Paul for reelection The Hill's Morning Report - Biden: Let's make a deal on infrastructure, taxes MORE as well as Democratic Govs. Gretchen WhitmerGretchen WhitmerGottlieb: Biden administration needs to think about surging resources into COVID-19 hotspots Michigan governor pushes back on criticism that state isn't being efficient in vaccinations Sunday shows preview: Democrats eye two-part infrastructure push; Michigan coronavirus cases surge MORE (Mich.), Andrew CuomoAndrew CuomoPolice reforms are a minefield, even in progressive communities New York City's suicide mission should alarm the entire nation New York's wealthy could face 51.8 percent tax rate: report MORE (N.Y.), and Gavin NewsomGavin NewsomCalifornia to spend 6M on wildfire prevention Former Trump campaign manager advising Jenner on potential California gubernatorial run Overnight Health Care: Biden says US still in 'life and death race' with virus | White House rules out involvement in 'vaccine passports' | Arkansas lawmakers override Hutchinson veto on transgender bill MORE (Calif.).

Targeting the somewhat confusing guidance related to when various groups of Americans will be able to be vaccinated, Fauci, played by Kate McKinnon, hosted a mock game show entitled, "So You Think You Can Get The Vaccine."

"The vaccine rollout is going strong, but it's also very confusing. Who can get it? How? When? Where is it? Do both doses go in the same arm or different arms or what? I don't know," McKinnon's Fauci says.

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At one point in the game show, the three "governors" decide that an older contestant played by "SNL's" Mikey Day, is eligible for the vaccine. But another problem arises.

"I'm just getting word that power went out at a CVS nearby and all of the vaccines are going to expire. So it's first come, first stab," says McKinnon's Fauci.

The controversy that arose after Texas Sen. Ted CruzRafael (Ted) Edward CruzBoehner: Trump 'stepped all over their loyalty' by lying to followers The Memo: Biden's five biggest foreign policy challenges Boehner finally calls it as he sees it MORE (R) left his state for Cancun, Mexico while a major snowstorm left millions without power was also highlighted.

"[I]t is great to be back in New York City," cast member Aidy Bryant, portraying Cruz, says. "I'm sorry, my arms are tired because I just flew back from Cancun."

"Uh oh. Uh oh. Here comes my catchphrase that I spent all day yesterday screaming...are you ready? Here we go. Freedooooooom!" she continued.

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The appearance was Bryant's second mocking Cruz.  Last week, she appeared on the show as the Texas senator, that time clad in a floral-print shirt, a tan, and a wig resembling the one worn by actor James Franco in his drug-slinging "Spring Breakers" role.

The show resumed its 46th season in late January. The latest episode was hosted by musician Nick Jonas, who also performed as the episode's musical guest.