HBO’s Bill MaherWilliam (Bill) MaherCleveland Indians name change to Guardians profoundly stupid, unnecessary The steady erosion of Trump-hate is a growing problem for Team Biden Comedians are right: Authoritarian Democrats are also a problem MORE went after Sen. Joe ManchinJoe ManchinWhy Biden's Interior Department isn't shutting down oil and gas Overnight Energy: Senate panel advances controversial public lands nominee | Nevada Democrat introduces bill requiring feds to develop fire management plan | NJ requiring public water systems to replace lead pipes in 10 years Transit funding, broadband holding up infrastructure deal MORE (D-W.Va.) during his show Friday night, dubbing the moderate Democrat the “most powerful Republican in the Senate.”

The comedian and liberal commentator knocked Manchin while opening his show “Real Time with Bill Maher,” noting that President BidenJoe BidenTrump hails Arizona Senate for audit at Phoenix rally, slams governor Republicans focus tax hike opposition on capital gains change Biden on hecklers: 'This is not a Trump rally. Let 'em holler' MORE would meet with Queen Elizabeth II on Sunday at the conclusion of the Group of Seven summit.

“Sunday, Biden is gonna go to Windsor Castle to meet with the queen, newly widowed queen. He was going to express his condolences for her losing Prince Philip, and she’s going to express her condolences for Joe losing Joe Manchin,” Maher said, drawing laughter from his audience.

ADVERTISEMENT

“This Joe Manchin. Boy, have you been reading about him? For a Democrat, he is the most powerful Republican in the Senate,” Maher continued.

Manchin, a conservative Democrat, has proved to be a key vote in the evenly divided Senate but has drawn the ire of the party’s progressive wing.

The West Virginia senator has been firm in his support of the filibuster, making it challenging for Democrats to attract the votes necessary to nix it. Instead, Manchin has consistently insisted on bipartisanship.

Last week, he wrote in the Charleston Gazette-Mail that he would vote against the For the People Act, the sweeping bill to overhaul elections at the top of Democrats’ priority list.

ADVERTISEMENT

Rep. Jamaal Bowman (D-N.Y.) last week called Manchin "the new Mitch McConnellAddison (Mitch) Mitchell McConnellHouse Democrats grow frustrated as they feel ignored by Senate Democrats question GOP shift on vaccines Has Trump beaten the system? MORE." 

Maher also slammed Manchin, saying he’s “blocked every big thing the Democrats want to do,” from the elections bill to infrastructure.

“The voting rights legislation, the Jan. 6 commission, even infrastructure. That’s f---ing dead now,” Maher said.

“The talks broke down they said because of — I love this — irreconcilable differences, which sounds to me like a marriage or a divorce, which is appropriate considering next year they may get the House,” he said.