Story at a glance:

  • “On LSD, the brain spent less time on higher-level processing and more on the sensory-driven activities.”
  • LSD also reduced the amount of energy the brain needs to switch from one state to another, allowing the mind to wander more freely.
  • Scientists have found evidence that LSD, a psychedelic drug, lowers one’s mental barriers to enable people to make new thoughts not based on what one knows but based on their curiosities, The Guardian reported.

    “Normally, our thoughts and incoming information are filtered by our prior experience,” Parker Singleton, a doctorate student at Cornell University, said. “But if you take that filtering and suppression away, you are looking at the world with new eyes. You get a totally new perspective.”


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    The brain is what scientists are calling a "prediction engine," and these predictions are based on prior experience to determine the outcomes.

    The brain works differently on psychedelics, and LSD makes people think differently from what normally influences their brains and allows them to develop a sense of the world from a new perspective.

    “You can imagine you might experience altered perceptions,” Amy Kuceyeski, a senior author on the study at Cornell, said. “If your prior belief is that walls don’t move and your prior belief melts, then that wall may appear to move.”

    While examining people on placebo or LSD, scientists say there are four kinds of states, or patterns of activity, the brain switches between.

    Two of the brain states were largely driven by sensory parts of the brain, while the other two involved the kind of top-down processing the brain performs to make sense of the world,” according to The Guardian. “On LSD, the brain spent less time on higher-level processing and more on the sensory-driven activities.”

    LSD also reduced the amount of energy the brain needs to switch from one state to another, allowing the brain to both wander and communicate more freely.


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    Published on May 19, 2021