President Trump approved an emergency declaration for Mississippi on Saturday as Category 1 Hurricane Nate made landfall in southeast Louisiana.
The storm is expected to hit Mississippi later Saturday night.
The declaration authorizes the Federal Emergency Management Agency (FEMA) to coordinate all disaster relief work, supplementing local and state work.
The storm currently has sustained winds of 85 mph, and has already soaked parts of Louisiana and Alabama.
Despite the storm's category being low, officials stressed the importance of safety and preparedness ahead of the storm.
"The storm surge is a big thing that really traps everyone," Biloxi, Miss., Mayor Andrew Gilich told CNN.
There were no mandatory evacuation orders in the state, but Jackson County, which is located on the Gulf Coast, issued a 7 p.m. curfew.
Gov. Phil Bryant (R) urged people in the state's coastal regions to head north.
The is the third Hurricane in six weeks to hit the U.S. mainland.
Hurricane Harvey brought catastrophic floods to Texas and parts of Louisiana in August, while Hurricane Irma brought heavy winds across Florida's Atlantic and Gulf coasts.