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Jill Biden on Lindsey Graham: 'We used to be great friends, and now he's changed'

Jill Biden, the wife of former Vice President Joe BidenJoe BidenBiden prepares to confront Putin Ukrainian president thanks G-7 nations for statement of support Biden aims to bolster troubled Turkey ties in first Erdoğan meeting MORE, said Monday it was “hard” to continue considering Sen. Lindsey GrahamLindsey Olin GrahamProgressives want to tighten screws beyond Manchin and Sinema GOP senators applaud Biden for global vaccine donation plans Lindsey Graham: Dismissal of Wuhan lab leak theory cost Trump 2020 election MORE (R-S.C.) a friend amid his announcement that he intends to investigate her family.

"Well, you know, Lindsey — I don't know what happened to Lindsey. And we used to be great friends and friends with John McCainJohn Sidney McCainMeghan McCain: Harris 'sounded like a moron' discussing immigration Arizona AG Mark Brnovich launches Senate challenge to Mark Kelly Arizona Democrats launch voter outreach effort ahead of key Senate race MORE," Biden said on CNN’s “New Day” Monday, referring to the late senator. "I mean, we traveled together with the Foreign Relations Committee. We've had dinner, you know, and now he's changed."

Asked by CNN’s John Berman if she still considers Graham a friend, Biden responded, "You know, it's hard when you, I don't know, consider somebody a friend and then they've said so many things, so many negative things. And it's — that's been a little hurtful."

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Graham, one of President TrumpDonald TrumpBiden prepares to confront Putin Biden aims to bolster troubled Turkey ties in first Erdoğan meeting Senate investigation of insurrection falls short MORE’s most vocal allies in the Senate, has continued to refer to the former vice president as a friend even as he says Hunter Biden’s business dealings in Ukraine should be investigated.

"I think this is a defining moment in the Biden campaign. Joe Biden is truly a friend. ... I think he’s a good man. But what Hunter Biden did was wrong at every level," Graham told Fox News anchor Bret Baier in October. "I think what Hunter Biden did does not pass the smell test."

Joe Biden, who has repeatedly claimed during his presidential campaign that Republican senators would be willing to work with him as president, expressed frustration about Graham in November, telling CNN’s Don LemonDon Carlton LemonClub for Growth bashes CNN in social media ad CNN ramps up streaming plans ahead of Discovery merger: report Second person arrested in assault of Jewish man near Times Square MORE, “I am disappointed, and quite frankly I'm angered, by the fact — he knows me; he knows my son; he knows there's nothing to this.”