Second Republican senator to vote against DeVos

Sen. Lisa MurkowskiLisa Ann MurkowskiDemocrats look for plan B on filibuster Senate will vote on John Lewis voting bill as soon as next week Overnight Health Care — Presented by Carequest — FDA moves to sell hearing aids over-the-counter MORE (R-Alaska) announced that she would not be voting for President Trump’s pick to lead the Education Department, becoming the second Republican senator to oppose Betsy DeVos's nomination.

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Murkowski made her announcement on the Senate floor, just after GOP Sen. Susan CollinsSusan Margaret CollinsThe Hill's Morning Report - Presented by Uber - Biden makes his pitch as tax questions mount Emanuel defends handling of Chicago police shooting amid opposition to nomination Emanuel to take hot seat in Senate confirmation hearing MORE (Maine) announced she would oppose DeVos.

The pair are the first two Republicans to break with President Trump on his Cabinet nominees. Their no votes will make it difficult for DeVos to be confirmed. Republicans hold 52 seats in the Senate. If every Democrat votes against DeVos, Vice President Pence could break the tie.

No Democrats have said they will vote for DeVos.

"I have serious concerns about a nominee to be secretary of Education ... who has been so immersed in the discussion of vouchers," she said.

"I do not intend to vote on final passage to support Ms. DeVos to be secretary of Education," she said.