GOP Sen. Lamar Alexander won't seek reelection

Sen. Lamar AlexanderAndrew (Lamar) Lamar AlexanderChina stalled reporting genetic information about COVID-19, angering WHO: report Senate GOP chairman criticizes Trump withdrawal from WHO Trump: US 'terminating' relationship with WHO MORE (R-Tenn.) on Monday announced that he will not run for reelection in 2020.

"I will not be a candidate for re-election to the United States Senate in 2020. The people of Tennessee have been very generous, electing me to serve more combined years as Governor and Senator than anyone else from our state," Alexander said.

Alexander, who has been in the Senate since 2003, said he will serve out the remainder of his term, which runs through the end of 2020. 

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"I have gotten up every day thinking that I could help make our state and country a little better, and gone to bed most nights thinking that I have. I will continue to serve with that same spirit during the remaining two years of my term," he added.

Alexander, 78, is the first senator up in 2020 to announce that they won't seek reelection. Republicans face a challenging map during the next cycle, where they'll be defending approximately 22 seats, including in states like Colorado and Maine, which Democratic presidential nominee Hillary ClintonHillary Diane Rodham ClintonTrump, Biden battle to shape opinion on scenes of unrest Sessions accepts 'Fox News Sunday' invitation to debate, Tuberville declines The Memo: Trump lags in polls as crises press MORE won in 2016.

Alexander is also the latest in a string of GOP chairmen from the establishment wing of the party to announce that they will retire during the Trump era: Senate Finance Committee Chairman Orrin HatchOrrin Grant HatchBottom line Bottom line Bottom line MORE (R-Utah) and Senate Foreign Relations Committee Chairman Bob CorkerRobert (Bob) Phillips CorkerTrump asserts his power over Republicans Romney is only GOP senator not on new White House coronavirus task force McConnell, Romney vie for influence over Trump's trial MORE (R-Tenn.) are retiring at the end of the current Congress.

Corker, on Monday, called working with Alexander "one of the highlights" of his work in the Senate.

"As one of the finest statesmen our state has ever seen, Lamar will leave behind a remarkable legacy. I know he will press through the next two years with great vigor, and I look forward to all he will accomplish on behalf of Tennesseans as he completes his service in Washington," Corker said in a statement.

Alexander previously served as chairman of the Senate Republican Conference and is considered to be close to both Majority Leader Mitch McConnellAddison (Mitch) Mitchell McConnellTrump congratulates Steve King challenger on GOP primary win The Hill's Morning Report - Protesters' defiance met with calls to listen Republicans turning against new round of ,200 rebate checks MORE (R-Ky.) and Minority Leader Charles SchumerCharles (Chuck) Ellis SchumerMcConnell blocks resolution condemning Trump over treatment of protesters House Democrat demands answers from Secret Service about role breaking up White House protests Pelosi, Schumer say treatment of protesters outside White House 'dishonors every value that faith teaches us' MORE (D-N.Y.).

He's also been at the center of some of the biggest fights in the Trump administration because of his position as chairman of the Health, Education, Labor and Pensions (HELP) Committee. 

He was part of a working group of GOP senators, assembled by McConnell, that crafted the Senate GOP's failed ObamaCare replacement bill last year. 

But Democrats have credited him with being willing to work with them on key issues despite growing partisanship in the Senate. 

He crafted a deal with Sen. Patty MurrayPatricia (Patty) Lynn MurrayCOVID-19 workplace complaints surge; unions rip administration Lack of child care poses major hurdle as businesses reopen Democratic leaders say Trump testing strategy is 'to deny the truth' about lack of supplies MORE (D-Wash.), the top Democrat on the health committee, to funds key payments to health insurers for two years.

He was also one of less than 10 GOP senators who voted for a bipartisan immigration proposal earlier this year that would have provided approximately 1.8 million immigrants brought to the United States illegally as children an eventual pathway to citizenship in exchange for $25 billion in border security. 

Sen. Ed MarkeyEdward (Ed) John MarkeyGOP Massachusetts governor: Trump's compassion 'nowhere to be found' Markey calls Trump 'scum' over comments on George Floyd protests Bipartisan senators call for investigation of TikTok's child privacy policies MORE (D-Mass.) on Monday also credit Alexander as being a "true partner" in addressing the country's opioid epidemic. 

Alexander's decision to retire will leave a hole in Tennessee politics, where he has been a mainstay for decades. He was first elected to the Senate in 2002, previously served as governor of Tennessee and made two unsuccessful bids for the White House in 1996 and 2000.

But he was considered potentially vulnerable to a primary challenge in 2020 after winning narrowly fending off tea party challenger Rep. Joe Carr during the 2014 GOP primary. 

It's unclear who will vie to succeed Alexander. Tennessee Gov. Bill Haslam (R) flirted with a Senate bid in 2018. And state Sen. Mark GreenMark GreenScalise blasts Democrats for calling on certain companies to return PPP loans Scalise targets China, WHO response from coronavirus oversight perch McCarthy unveils new GOP-led China task force MORE (R) hinted last year that he could make a Senate run in 2020.  

Green told USA Today in August that he would be "back in the election cycle" in 2020.

"I think that's going to be an opportunity for me potentially later," he added about a potential Senate run. 

President TrumpDonald John TrumpTrump says inviting Russia to G7 'a question of common sense' Pentagon chief does not support invoking Insurrection Act Dershowitz: Does President Trump have power to declare martial law? MORE won Tennessee by more than 26 points in 2016. In last month's election to replace Corker, Rep. Marsha BlackburnMarsha BlackburnGOP senators dodge on treatment of White House protesters Five things to know about Trump's legal power under the Insurrection Act Bipartisan senators call for investigation of TikTok's child privacy policies MORE (R-Tenn.) defeated former Gov. Phil Bredesen (D) by nearly 11 points.

Updated at 1:12 p.m.