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Roy Blunt won't run for Senate seat in 2022

Sen. Roy BluntRoy Dean BluntSenate GOP to face off over earmarks next week Greitens Senate bid creates headache for GOP Biden outreach on infrastructure met with Republican skepticism MORE (Mo.), a member of GOP leadership, announced on Monday that he won't run for reelection in 2022 — marking the latest high-profile retirement for Senate Republicans.

“After 14 general election victories — three to county office, seven to the United States House of Representatives, and four statewide elections — I won’t be a candidate for reelection to the United States Senate next year," Blunt said in a video.

Blunt, 71, said that he will finish out his current term, which runs through 2022. Blunt was first elected to the Senate in 2010 and previously served 14 years in the House, where he was also a member of GOP leadership. 

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He's the fifth Senate Republican expected not to seek reelection next year.

Sens. Pat ToomeyPatrick (Pat) Joseph ToomeySasse rebuked by Nebraska Republican Party over impeachment vote Philly GOP commissioner on censures: 'I would suggest they censure Republican elected officials who are lying' Toomey censured by several Pennsylvania county GOP committees over impeachment vote MORE (R-Pa.), Rob PortmanRobert (Rob) Jones PortmanOVERNIGHT ENERGY: Senate confirms Mallory to lead White House environment council | US emissions dropped 1.7 percent in 2019 | Interior further delays Trump rule that would make drillers pay less to feds Senate confirms Biden's pick to lead White House environmental council Biden outreach on infrastructure met with Republican skepticism MORE (R-Ohio) and Richard ShelbyRichard Craig ShelbySenate GOP to face off over earmarks next week Senate GOP opens door to earmarks Five takeaways from Biden's first budget proposal MORE (R-Ala.) have all announced that they will retire at the end of their current term. Sen. Richard BurrRichard Mauze BurrFormer Gov. Pat McCrory enters GOP Senate race in North Carolina Lara Trump leads GOP field in North Carolina Senate race, poll shows Former North Carolina governor set to launch Senate bid MORE (R-N.C.) has also previously indicated he won't run for reelection.

Sens. Chuck GrassleyChuck GrassleyAnti-Asian hate crimes bill overcomes first Senate hurdle On The Money: Senate confirms Gensler to lead SEC | Senate GOP to face off over earmarks next week | Top Republican on House tax panel to retire Democrats get good news from IRS MORE (R-Iowa) and Ron JohnsonRonald (Ron) Harold JohnsonPelosi: Dropping 9/11-style Jan. 6 commission an 'option' amid opposition Wisconsin state Treasurer Sarah Godlewski launches Senate bid Biden picks vocal Trump critics to lead immigration agencies MORE (R-Wis.) haven't yet said if they will run for reelection.

Grassley, 87, has told reporters that he'll make a decision this fall. Johnson, who had previously made a vow to only run for two terms, said last week that leaving office after 2022 was "probably my preference now."

Republicans only need to pick up one seat next year to win back the majority. But they are defending a total of 20 seats, compared to 14 for Democrats, including two seats in states that President BidenJoe BidenHouse panel approves bill to set up commission on reparations Democrats to offer bill to expand Supreme Court Former Israeli prime minister advises Iran to 'cool down' amid nuclear threats MORE won: Pennsylvania and Wisconsin.

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Though Democrats have been able to historically win Senate seats in Missouri, the state has swung hard toward Republicans and will likely start out as a safe Republican seat. Sen. Josh HawleyJoshua (Josh) David HawleyAnti-Asian hate crimes bill overcomes first Senate hurdle Republicans see record fundraising in months after Capitol breach Biden sparks bipartisan backlash on Afghanistan withdrawal  MORE (R-Mo.) defeated the state's most recent Democratic senator, Claire McCaskillClaire Conner McCaskillGreitens Senate bid creates headache for GOP The Hill's Morning Report - Biden tasks Harris on border; news conference today Missouri Senate candidate Eric Greitens tangles with Hugh Hewitt in testy interview MORE, in 2018 and former President TrumpDonald TrumpTrump mocks Murkowski, Cheney election chances Race debate grips Congress US reentry to Paris agreement adds momentum to cities' sustainability efforts MORE won nearly 57 percent of the vote last year.

Former Missouri Secretary of State Jason Kander, who came within three points of Blunt in 2016, indicated on Monday that he will not run for the seat.

"Regarding the Senate in ‘22: Always nice to be asked. Thanks. My decision not to run was never about who I’d run against. I’m the President of @VCP_HQ and we’re building campuses for vets around the USA. Love this work, don’t want a new job. I’ll campaign for the Dem nominee!" Kander tweeted shortly after Blunt's announcement.

McCaskill also took herself out of the running Monday, saying on Twitter that, "I will never run for office again."

Blunt's retirement marks the latest blow for the institutionalist wing of the Senate GOP caucus, which has lost several members in recent election cycles. Sens. Bob CorkerRobert (Bob) Phillips CorkerFox News inks contributor deal with former Democratic House member Senate GOP faces retirement brain drain Roy Blunt won't run for Senate seat in 2022 MORE (Tenn.), Lamar AlexanderLamar AlexanderSenate GOP faces retirement brain drain The Hill's Morning Report - Presented by the National Shooting Sports Foundation - CDC news on gatherings a step toward normality Blunt's retirement deals blow to McConnell inner circle MORE (Tenn.) and Pat RobertsCharles (Pat) Patrick RobertsSenate GOP faces retirement brain drain Roy Blunt won't run for Senate seat in 2022 Lobbying world MORE (Kan.) — committee chairmen known for their ability to cut deals — have retired over the past two cycles.

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Shelby, Blunt, Portman and Burr are also all ranking members of Senate committees, with their decisions to retire likely to set off a game of musical chairs among Senate Republicans for the plum positions. Blunt's decision is a shift from as recently as late January, where he seemed to indicate that he was likely to run for reelection.

"I'm planning to run but I haven't made an announcement on that yet. I'll wait for my announcement to officially decide what I'm going to do," he told reporters at the time.

Updated at 12:05 p.m.