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Despite successful attacks in Paris and Brussels, the Islamic State in Iraq and Syria’s (ISIS) home base in the Middle East is collapsing, Secretary of State John Kerry said Friday in Belgium.

“Its territory is shrinking every day,” Kerry said. “Its leaders are being decimated, its revenue sources are dwindling, and its fighters are fleeing.”

{mosads}Kerry’s comments come after reports that two Americans were among the 31 killed in Tuesday’s attacks in Brussels, where he arrived Friday.

There have been few details about the Americans who may have been injured or killed, but officials have said there are “at least” four known to be missing.

“As we have said many times, President Obama, myself and others, our mission to destroy and defeat Daesh is not going to happen overnight,” Kerry said, using an Arabic term for ISIS that is considered derogatory by its members.

Kerry added that 66 nations, including Belgium, have joined a coalition dedicated to eradicating ISIS.

“It’s going to take some time and patience and persistence. It will require resources and commitment and cooperation across many cultures and beliefs, and the recognition that this is in fact a global challenge, but I am absolutely confident that we’ll be successful.”

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